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公开(公告)号：EP1578905A2
公开(公告)日：2005-09-28
申请号：EP02765778.2
申请日：2002-06-04
申请人： Curagen Corporation
发明人： AGEE, Michele L. , ANDERSON, David W. , BERGHS, Constance , CASMAN, Stacie J. , CATTERTON, Elina , DIPIPPO, Vincent A. , EDINGER, Shlomit R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GUO, Xiaojia , HERRMANN, John L. , HJALT, Tord , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai V. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel M. , MILLER, Charles E. , MILLET, Isabelle , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol E.A. , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SHENOY, Suresh G. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPADERNA, Steven K. , SPYTEK, Kimberly A. , STONE, David J. , VERNET, Corine A.M. , ZHONG, Haihong , ZHONG, Mei , ALSOBROOK, John P.,II , BURGESS, Catherine E. , LEPLEY, Denise M.
IPC分类号： C12N1/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。
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2.发明公开
公开(公告)号：EP1443913A2
公开(公告)日：2004-08-11
申请号：EP02807153.8
申请日：2002-07-03
申请人： Curagen Corporation
发明人： LI, Li , SHENOY, Suresh, G. , PATTURAJAN, Meera , ELLERMAN, Karen , GORMAN, Linda , ZHONG, Mei , CATTERTON, Elina , SPYTEK, Kimberly, A. , MILLER, Charles, E. , EDINGER, Shlomit, R. , HJALT, Tord , GERLACH, Valerie, L. , SHIMKETS, Richard, A. , TAUPIER, Raymond, J., Jr. , ANDERSON, David, W. , GUO, Xiaojia , BAUMGARTNER, Jason, C. , PADIGARU, Muralidhara , PEYMAN, John, A. , SMITHSON, Glennda , CASMAN, Stacie J. , VOSS, Edward Z. , BOLDOG, Ferenc L. , PENA, Carol E.A. , CHAPOVAL, Andrei , RASTELLI, Luca , KEKUDA, Ramesh , VERNET, Corine A.M.
IPC分类号： A61K31/00
摘要： The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.
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3.发明公开NOVEL ANTIBODIES THAT BIND TO ANTIGENIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE ANTIGENS, AND METHODS OF USE 审中-公开新抗体的抗基因多肽结合抗基因编码核酸及使用方法
公开(公告)号：EP1401470A2
公开(公告)日：2004-03-31
申请号：EP02732027.4
申请日：2002-06-04
申请人： Curagen Corporation
发明人： ANDERSON, David, W. , ZERHUSEN, Bryan, D. , LI, Li , ZHONG, Mei , CASMAN, Stacie, J. , GERLACH, Valerie, L. , SHIMKETS, Richard, A. , GORMAN, Linda , PENA, Carol, E., A. , KEKUDA, Ramesh , PATTURAJAN, Meera , SPYTEK, Kimberly, A. , LEITE, Mario, W. , RASTELLI, Luca , MACDOUGALL, John, R. , TAUPIER, Raymond, J., Jr. , GUO, Xiaojia , MILLER, Charles, E. , SHENOY, Suresh, G. , HJALT, Tord , VOSS, Edward Z. , BOLDOG, Ferenc L. , MALYANKAR, Uriel M. , PADIGARU, Muralidhara , JI, Weizhen , SMITHSON, Glennda , EDINGER, Shlomit R. , MILLET, Isabelle , ELLERMAN, Karen
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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公开(公告)号：EP1492807A2
公开(公告)日：2005-01-05
申请号：EP02806720.5
申请日：2002-08-02
申请人： Curagen Corporation
发明人： ZERHUSEN, Bryan, D , PATTURAJAN, Meera , KEKUDA, Ramesh , MILLER, Charles, E , RIEGER, Daniel,K , PENA, Carol,E, A , SHIMKETS, Richard, A , LI,Li , BERGHS, Constance , ZHONG, Mei , CASMAN, Stacie, J , VOSS, Edward, Z , BOLDOG,Ferenc, L , PADIGARU, Muralidhara , SMITHSON, Glennda , SHENOY, Suresh, G , JI, Weizhen , GORMAN, Linda , VERNET, Corine, A, M. , LEITE, Mario, W , GUO, Xiaojia , ANDERSON, David, W , SPYTEK, Kimberly,A , GERLACH, Valerie, L , BURGESS, Catherine, E , KHRAMTSOV, Nikolai, V , ORT, Tatiana , ELLERMAN, Karen , RASTELLI, Luca , AGEE, Michele, L , CHAUDHURI, Amitabha , CHANT, John, S , DIPIPPO, Vicent, A , EDINGER, Shlomit, R , EISEN, Andrew , GANGOLLI, Esha,A , GIOT, Loic , OOI, Chean, Eng , ROTHENBERG, Mark, E , SPADERNA, Steven,K , HJALT, Tord , LIU, Xiaohong , TAUPIER, Raymond J,Jr , CATTERTON, Elina
IPC分类号： C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1451346A2
公开(公告)日：2004-09-01
申请号：EP02757157.9
申请日：2002-08-16
申请人： Curagen Corporation
发明人： HJALT, Tord
CPC分类号： C12Q1/6837 , C12Q1/6813 , C12Q1/6865 , C12Q2525/179 , C12Q2525/143
摘要： A novel method of labelling cRNAs for probing oligo-based microarrays is disclosed. The polynucleotide template of interest is reverse transcribed into double-stranded cDNA using random primers that include an RNA polymerase promoter. This cDNA is then used as a template for synthesis of labeled RNA via in vitro transcription in the presence of labeled precursors.
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6.发明公开THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开治疗性多肽，核酸对这种字符，和方法的应用
公开(公告)号：EP1401858A2
公开(公告)日：2004-03-31
申请号：EP02739617.5
申请日：2002-06-04
申请人： Curagen Corporation
发明人： ANDERSON, David, W. , BAUMGARTNER, Jason, C. , BOLDOG, Ferenc, L. , CASMAN, Stacie, J. , EDINGER, Schlomit, R. , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GUO, Xiaojia , HJALT, Tord , KEKUDA, Ramesh , LI, Li , MACDOUGALL, John, R. , MALYANKAR, Uriel, M. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RASTELLI, Luca , SHIMKETS, Richard A. , STONE, DAVID J. , SPYTEK, Kimberly A. , VERNET, Corine A.M. , VOSS, Edward Z. , ZERHUSEN, Bryan D.
IPC分类号： C07K1/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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7.发明公开NOVEL HUMAN PROTEINS, POLYNUCLEOTIDES ENCODING THEM AND METHODS OF USING THE SAME 审中-公开新的人类蛋白质，多核苷酸编码本而方法
公开(公告)号：EP1401486A2
公开(公告)日：2004-03-31
申请号：EP02732026.6
申请日：2002-06-04
申请人： Curagen Corporation
发明人： ZERHUSEN, Bryan, D. , KEKUDA, Ramesh , SPYTEK, Kimberly, A. , SHENOY, Suresh, G. , MILLER, Charles, E. , HJALT, Tord , GERLACH, Valerie, L. , BAUMGARTNER, Jason, C. , GUO, Xiaojia , GANGOLLI, Esha, A. , VERNET, Corine, A., M. , PADIGARU, Muralidhara , LI, Li , PENA, Carol, E., A. , GORMAN, Linda , ANDERSON, David, W. , EDINGER, Shlomit, R. , PATTURAJAN, Meera , STONE, David, J.
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
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