公开(公告)号：EP1427749A2

公开(公告)日：2004-06-16

申请号：EP02713788.4

申请日：2002-03-08

申请人： Curagen Corporation

发明人： PADIGARU, Muralidhara ,  SPYTEK, Kimberly,A ,  SHENOY, Suresh,G ,  TAUPIER, Raymond, J ,  PENA, Carol,E, A ,  LI, Li ,  ZERHUSEN, Bryan,D ,  GUSEV, Vladimir ,  JI, Weizhen ,  GORMAN, Linda ,  MILLER, Charles, E ,  KEKUDA, Ramesh ,  PATTURAJAN, Meera ,  GANGOLLI, Esha ,  VERNET,Corine, A.M ,  GUO,Xiaojia ,  TCHERNEV, Velizar ,  FERNANDES, Elma, R ,  CASMAN, Stacie, J ,  GERLACH, Valerie ,  LIU, Yi ,  ANDERSON, David ,  SPANDERNA, Steven,K ,  CATTERTON, Elina ,  BURGESS, Catherine ,  LEITE, Mario ,  ZHONG, Haihong ,  ALSOBROOK, John,P.II ,  LEPLEY, Denise, M ,  RIEGER, Daniel,K ,  MALYANKAR, Uriel M.

IPC分类号： C07K1/00 ,  A61K38/00 ,  C12Q1/68 ,  C12P21/06 ,  C07H21/00

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

公开(公告)号：EP1141878A2

公开(公告)日：2001-10-10

申请号：EP00903107.1

申请日：2000-01-05

申请人： Curagen Corporation

发明人： BADER, Joel, S. ,  LIU, Yi ,  GOLD, Stephen ,  DZIUDA, Darius ,  GUSEV, Vladimir ,  JUDSON, Richard, S. ,  WENT, Gregory, T.

IPC分类号： G06F19/00

摘要： This invention relates to a method of identifying a difference between at least two data sets made up of ordered elements utilizing internal features within the data sets for calculations relating to normalization, scaling, and difference finding.

公开(公告)号：EP1409536A2

公开(公告)日：2004-04-21

申请号：EP02765832.7

申请日：2002-02-12

申请人： Curagen Corporation

发明人： GUO, Xiaojia ,  FERNANDES, Elma ,  LI, Li ,  KEKUDA, Ramesh ,  LIU, Yi ,  LEITE, Mario ,  SPYTEK, Kimberly, A. ,  JI, Weizhen ,  CASMAN, Stacie J. ,  BOLDOG, Ference L. ,  PATTURAJAN, Meera ,  VERNET, Corine A.M. ,  BALLINGER, Robert, A. ,  MALYANKAR, Uriel, M. ,  TCHERNEV, Velizar, T. ,  BLALOCK, Angela, D. ,  GUSEV, Vladimir, Y. ,  RASTELLI, Luca ,  MEZES, Peter, D. ,  ELLERMAN, Karen ,  HEYES, Melvyn ,  HERRMANN, John L. ,  SHIMKETS, Richard A. ,  IOIME, Noelle ,  PENA, Carel E.A. ,  SHENOY, Suresh G. ,  TAUPIER, Raymond J., Jr. ,  GERLACH, Valerie ,  GORMAN, Linda

IPC分类号： C07K14/47 ,  C12N15/12 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/50 ,  A61K38/17 ,  A61K31/7088 ,  A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving anyone of these novel human nucleic acids and proteins.