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    NOVEL BENZOTHIOPHENE DERIVATIVES
    1.
    发明公开
    NOVEL BENZOTHIOPHENE DERIVATIVES 审中-公开
    新型苯并噻吩衍生物

    公开(公告)号：EP1283209A1

    公开(公告)日：2003-02-12

    申请号：EP01932147.0

    申请日：2001-05-18

    申请人： DAIICHI PHARMACEUTICAL CO., LTD.

    发明人： SHIMADA, Shin'ichi ,  NOMOTO, Shin, Erumezongakuenminami 2-303 ,  OKUE, Masayuki ,  KIMURA, Ken'ichi ,  NAKAMURA, Junji ,  IKEDA, Yoshikazu ,  TAKADA, Takeko

    IPC分类号： C07D409/04 ,  C07D417/04 ,  A61K31/4436 ,  A61K31/427 ,  A61P5/28 ,  A61P5/32 ,  A61P35/00

    CPC分类号： C07D409/04 ,  C07D409/14 ,  C07D417/04

    摘要： The present invention relates to novel benzothiophene derivatives represnted by the following formula (I) or salts thereof, inhibitors of steroid 17α-hydroxylase and/or C17-20 lyase, and pharmaceutical compositions containing the benzothiophene derivative or the salt.
    wherein Ar shows a substituted or unsubstituted aromatic heterocyclic group; R shows a hydroxyl group, lower alkyl group, lower alkyloxy group, halogen atom, carboxyl group, lower alkyloxycarbonyl group, carbamoyl group, amino group, amino group which may be substituted or not substituted with one or more substituents selected from a lower alkyl group and lower acyl group, cyano group, substituted or unsubstituted phenyl group, substituted or unsubstituted phenoxy group, substituted or unsubstituted phenyl lower alkyl group, substituted or unsubstituted phenyl lower alkyloxy group, or substituted or unsubstituted aromatic heterocyclic group.

    摘要翻译： 本发明涉及由下式（I）表示的新型苯并噻吩衍生物或其盐，类固醇17α-羟化酶和/或C17-20裂解酶抑制剂，以及含有该苯并噻吩衍生物或其盐的药物组合物。 Ar表示取代或未取代的芳香族杂环基， R表示羟基，低级烷基，低级烷氧基，卤素原子，羧基，低级烷氧基羰基，氨基甲酰基，氨基，可被取代或未被一个或多个选自低级烷基 低级酰基，氰基，取代或未取代的苯基，取代或未取代的苯氧基，取代或未取代的苯基低级烷基，取代或未取代的苯基低级烷氧基或取代或未取代的芳香族杂环基。