公开(公告)号：EP0902022B1

公开(公告)日：2003-07-30

申请号：EP98900226.6

申请日：1998-01-13

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： YOSHIHAMA, Makoto ,  NAKAKOSHI, Masamichi ,  NAKAMURA, Junji ,  NAKAYAMA, Shoji

IPC分类号： C07D307/83 ,  C07D407/06 ,  C07D405/06 ,  A61K31/34 ,  A61K31/40

CPC分类号： C07D405/06 ,  C07D307/83 ,  C07D407/06

摘要： Novel benzofuranone derivatives useful as a preventive or remedy for hormone-dependent diseases and represented by specific general formula (I). The production process comprises reacting a specific benzofuranone compound with a specific benzaldehyde compound.

公开(公告)号：EP0902003B1

公开(公告)日：2006-07-26

申请号：EP98901023.6

申请日：1998-01-28

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： YOSHIHAMA, Makoto ,  NAKAKOSHI, Masamichi ,  NAKAMURA, Junji ,  NAKAYAMA, Shoji

IPC分类号： C07C49/643 ,  C07C49/697 ,  C07C49/747 ,  C07C49/755 ,  C07C45/74 ,  C07C225/22 ,  C07D311/22 ,  A61K31/12 ,  A61K31/135 ,  A61K31/35

CPC分类号： C07D407/06 ,  C07C45/74 ,  C07C49/747 ,  C07C49/755 ,  C07C65/40 ,  C07C225/22 ,  C07C2602/10 ,  C07D311/22 ,  C07D317/54 ,  C07D319/18

摘要： Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R1 and R2 each represents hydrogen, hydroxy, alkyloxy, or aralkyloxy; R3 to R7 each represents hydrogen, hydroxy, linear or branched C1-6 alkyl, alkyloxy, aralkyloxy, halogeno, or amino, or R3 and R4, R4 and R5, R5 and R6, or R6 and R7 are bonded to each other to form alkylenedioxy; and A represents methylene or oxygen. The derivatives are produced by reacting specific tetralone or benzopyranone derivatives with specific benzaldehyde derivatives.

公开(公告)号：EP1283208A1

公开(公告)日：2003-02-12

申请号：EP01932148.8

申请日：2001-05-18

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： SHIMADA, Shin'ichi ,  NOMOTO, Shin Erumezongakuenminami 2-303 ,  OKUE, Masayuki ,  KIMURA, Ken'ichi ,  NAKAMURA, Junji ,  IKEDA, Yoshikazu ,  TAKADA, Takeko

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  A61K31/443 ,  A61K31/4436 ,  A61P5/28 ,  A61P5/32 ,  A61P35/00

CPC分类号： C07D405/04 ,  C07D405/14 ,  C07D409/14

摘要： The present invention provides novel benzofuran derivatives represented by the following formula (I) or salts thereof:
wherein Py is a 2-, 3-, or 4-pyridyl group and R is a substituted or unsubstituted phenyl group or a substituted or unsubstituted aromatic heterocyclic group.
The present invention also relates to inhibitors of steroid 17α-hydroxylase and/or steroid C17-20 lyase and pharmaceutical compositions containing a benzofuran derivative of the above formula (I), or the salt.

摘要翻译： 本发明提供由下式（I）表示的新型苯并呋喃衍生物或其盐：其中Py是2-，3-或4-吡啶基，R是取代或未取代的苯基或取代或未取代的苯基 未取代的芳族杂环基。 本发明还涉及类固醇17α-羟化酶和/或类固醇C17-20裂解酶的抑制剂和含有上式（I）的苯并呋喃衍生物或其盐的药物组合物。

公开(公告)号：EP1283209A1

公开(公告)日：2003-02-12

申请号：EP01932147.0

申请日：2001-05-18

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： SHIMADA, Shin'ichi ,  NOMOTO, Shin, Erumezongakuenminami 2-303 ,  OKUE, Masayuki ,  KIMURA, Ken'ichi ,  NAKAMURA, Junji ,  IKEDA, Yoshikazu ,  TAKADA, Takeko

IPC分类号： C07D409/04 ,  C07D417/04 ,  A61K31/4436 ,  A61K31/427 ,  A61P5/28 ,  A61P5/32 ,  A61P35/00

CPC分类号： C07D409/04 ,  C07D409/14 ,  C07D417/04

摘要： The present invention relates to novel benzothiophene derivatives represnted by the following formula (I) or salts thereof, inhibitors of steroid 17α-hydroxylase and/or C17-20 lyase, and pharmaceutical compositions containing the benzothiophene derivative or the salt.
wherein Ar shows a substituted or unsubstituted aromatic heterocyclic group; R shows a hydroxyl group, lower alkyl group, lower alkyloxy group, halogen atom, carboxyl group, lower alkyloxycarbonyl group, carbamoyl group, amino group, amino group which may be substituted or not substituted with one or more substituents selected from a lower alkyl group and lower acyl group, cyano group, substituted or unsubstituted phenyl group, substituted or unsubstituted phenoxy group, substituted or unsubstituted phenyl lower alkyl group, substituted or unsubstituted phenyl lower alkyloxy group, or substituted or unsubstituted aromatic heterocyclic group.

摘要翻译： 本发明涉及由下式（I）表示的新型苯并噻吩衍生物或其盐，类固醇17α-羟化酶和/或C17-20裂解酶抑制剂，以及含有该苯并噻吩衍生物或其盐的药物组合物。 Ar表示取代或未取代的芳香族杂环基， R表示羟基，低级烷基，低级烷氧基，卤素原子，羧基，低级烷氧基羰基，氨基甲酰基，氨基，可被取代或未被一个或多个选自低级烷基 低级酰基，氰基，取代或未取代的苯基，取代或未取代的苯氧基，取代或未取代的苯基低级烷基，取代或未取代的苯基低级烷氧基或取代或未取代的芳香族杂环基。