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公开(公告)号：EP1028110B1
公开(公告)日：2004-04-14
申请号：EP98945556.3
申请日：1998-10-01
发明人： HARTMANN, Rolf, Wolfgang , WACHALL, Bertil , YOSHIHAMA, Makoto , NAKAKOSHI, Masamichi , NOMOTO, Shin, 2-303, Erumezon gakuenminami , IKEDA, Yoshikazu
IPC分类号： C07D213/16 , C07C13/48 , C07C39/23 , C07C43/21 , C07D233/64 , A61K31/44 , A61K31/415 , A61K31/025
CPC分类号： C07D213/30
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公开(公告)号：EP1001035B9
公开(公告)日：2006-11-08
申请号：EP97919709.2
申请日：1997-04-25
发明人： KIMURA, Ken-ichi , IKEDA, Yoshikazu , KAGAMI, Shinobu, Matsubara mansion 2A , TAKAHASHI, Hidetoshi , TAKAHASHI, Kousaku , YOSHIHAMA, Makoto , UBUKATA, Makoto , ISONO, Kiyoshi
CPC分类号： C07H19/06 , C12P19/385
摘要： Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
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3.发明授权NOVEL TETRALONE OR BENZOPYRANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 失效NEW己酮或苯并吡喃酮衍生物及其生产工艺
公开(公告)号：EP0902003B1
公开(公告)日：2006-07-26
申请号：EP98901023.6
申请日：1998-01-28
IPC分类号： C07C49/643 , C07C49/697 , C07C49/747 , C07C49/755 , C07C45/74 , C07C225/22 , C07D311/22 , A61K31/12 , A61K31/135 , A61K31/35
CPC分类号： C07D407/06 , C07C45/74 , C07C49/747 , C07C49/755 , C07C65/40 , C07C225/22 , C07C2602/10 , C07D311/22 , C07D317/54 , C07D319/18
摘要： Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R1 and R2 each represents hydrogen, hydroxy, alkyloxy, or aralkyloxy; R3 to R7 each represents hydrogen, hydroxy, linear or branched C1-6 alkyl, alkyloxy, aralkyloxy, halogeno, or amino, or R3 and R4, R4 and R5, R5 and R6, or R6 and R7 are bonded to each other to form alkylenedioxy; and A represents methylene or oxygen. The derivatives are produced by reacting specific tetralone or benzopyranone derivatives with specific benzaldehyde derivatives.
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公开(公告)号：EP1001035B1
公开(公告)日：2006-01-11
申请号：EP97919709.2
申请日：1997-04-25
发明人： KIMURA, Ken-ichi , IKEDA, Yoshikazu , KAGAMI, Shinobu, Matsubara mansion 2A , TAKAHASHI, Hidetoshi , TAKAHASHI, Kousaku , YOSHIHAMA, Makoto , UBUKATA, Makoto , ISONO, Kiyoshi
CPC分类号： C07H19/06 , C12P19/385
摘要： Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
摘要翻译： 具有新型化学结构的抗生素RK-1061及其制备方法。 它们具有由通式（I）表示的结构式，其中A表示R 1或R 1 CH（OR 2）CH 2，R 2表示3-甲基戊二酸残基，并且R 3表示硫酸根基团或氢原子。 该方法包括培养属于链霉菌属的射线真菌并从培养物中分离RK-1061。 Streptomyces sp.SN-1061M（FERM BP-5800）能够以高生产力稳定生产RK-1061。
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公开(公告)号：EP0902022B1
公开(公告)日：2003-07-30
申请号：EP98900226.6
申请日：1998-01-13
IPC分类号： C07D307/83 , C07D407/06 , C07D405/06 , A61K31/34 , A61K31/40
CPC分类号： C07D405/06 , C07D307/83 , C07D407/06
摘要： Novel benzofuranone derivatives useful as a preventive or remedy for hormone-dependent diseases and represented by specific general formula (I). The production process comprises reacting a specific benzofuranone compound with a specific benzaldehyde compound.
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公开(公告)号：EP0683237B1
公开(公告)日：2002-03-06
申请号：EP94914618.7
申请日：1994-05-13
IPC分类号： C12Q1/25
CPC分类号： G01N33/57407 , C12Q1/25 , G01N33/743
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