利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.018 秒)

    MACROCYCLIC KINASE INHIBITORS AND USES THEREOF
    3.
    发明公开
    MACROCYCLIC KINASE INHIBITORS AND USES THEREOF 审中-公开

    公开(公告)号：EP3172213A4

    公开(公告)日：2018-01-24

    申请号：EP15824907

    申请日：2015-07-21

    申请人： DANA FARBER CANCER INST INC

    发明人： GRAY NATHANAEL ,  CHOI HWAN GEUN ,  LIANG YANKE

    IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D498/08 ,  C07D498/18

    CPC分类号： C07D498/08 ,  C07D498/18

    摘要： The present disclosure provides macrocyclic compounds of Formula (I). The provided compounds are able to bind protein kinases and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase in a subject or cell and/or in treating or preventing a disease (e.g., proliferative disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

    IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF
    6.
    发明公开
    IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF 审中-公开

    公开(公告)号：EP3171874A4

    公开(公告)日：2017-12-27

    申请号：EP15824975

    申请日：2015-07-21

    申请人： DANA-FARBER CANCER INST INC

    发明人： CHOI HWAN GEUN ,  LIANG YANKE ,  GRAY NATHANAEL

    IPC分类号： A61K31/4178 ,  C07D233/88 ,  C07D403/04

    CPC分类号： C07D403/04 ,  C07D403/14

    摘要： The present disclosure provides imidazolyl compounds of Formula (I) and methods of preparing the compounds. The provided compounds are able to bind protein kinases and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase in a subject or cell and/or in treating or preventing a disease (e.g., proliferative disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.