公开(公告)号：EP3223816A4

公开(公告)日：2018-05-30

申请号：EP15862743

申请日：2015-11-24

申请人： THE J DAVID GLADSTONE INST

发明人： WEINBERGER LEOR S

IPC分类号： A61K31/4184 ,  A61P31/20

CPC分类号： A61K31/496 ,  A01N1/0215 ,  A61K31/522 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056 ,  A61K45/06 ,  A61K2300/00

摘要： The present disclosure provides a method for inhibiting cytomegalovirus (CMV) replication in a cell infected with CMV, the method comprising contacting the cell with a bisbenzimidazole compound. The present disclosure provides a method of treating a CMV infection in an individual, the method comprising administering to the individual an effective amount of a bisbenzimidazole compound.

公开(公告)号：EP2956557A4

公开(公告)日：2016-09-14

申请号：EP14751523

申请日：2014-02-13

申请人： DAVID GLADSTONE INST

发明人： WEINBERGER LEOR S

IPC分类号： C12Q1/70

CPC分类号： C12N15/86 ,  C12N2710/16122 ,  C12N2710/16143 ,  C12N2740/15043 ,  C12N2830/00 ,  C12N2830/48 ,  C12N2830/60 ,  C12N2840/203 ,  G01N33/5023

摘要： The present disclosure provides a recombinant expression vector comprising a nucleotide sequence encoding a herpesvirus transactivator, where the nucleotide sequence is operably linked to a herpesvirus control element. The present disclosure provides cell lines genetically modified to express a herpesvirus transactivator under the control of a herpesvirus control element. The present disclosure provides methods of identifying agents that disrupt feedback regulation of a herpesvirus transcriptional control element by a herpesvirus transactivator.

摘要翻译： 本公开内容提供了包含编码疱疹病毒反式激活，其中所述核苷酸序列可操作地连接到一个控制疱疹病毒元件的核苷酸序列的重组表达载体。 本发明提供了细胞系遗传修饰以表达疱疹病毒控制元件的控制下的反式激活的疱疹病毒。 本发明提供了鉴定剂的方法确实由疱疹病毒反式干扰疱疹病毒的转录控制元件的反馈调节。

公开(公告)号：EP2969006A4

公开(公告)日：2016-11-02

申请号：EP14770952

申请日：2014-03-13

申请人： DAVID GLADSTONE INST

发明人： WEINBERGER LEOR S ,  NOTTON TIMOTHY J

IPC分类号： A61P31/18 ,  C12N15/113

CPC分类号： A61K35/76 ,  A61K38/162 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16032 ,  C12N2740/16033 ,  C12N2740/16062 ,  A61K2300/00

摘要： The present disclosure provides an interfering, conditionally replicating human immunodeficiency virus (HIV) construct; infectious particles comprising the constructs; and compositions comprising the construct or the particle. The constructs, particles, and compositions are useful in methods of reducing HIV viral load in an individual, which methods are also provided.