利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.01 秒)

    SYSTEMS AND METHODS FOR SEQUENCING PEPTIDES BY MASS SPECTROMETRY
    2.
    发明公开
    SYSTEMS AND METHODS FOR SEQUENCING PEPTIDES BY MASS SPECTROMETRY 有权
    系统和方法进行测序肽按质量计

    公开(公告)号：EP2798658A1

    公开(公告)日：2014-11-05

    申请号：EP12861345.2

    申请日：2012-12-04

    申请人： DH Technologies Development Pte. Ltd.

    发明人： BONNER, Ron ,  TATE, Stephen

    IPC分类号： H01J49/26

    CPC分类号： G01N33/6848 ,  G06F19/18 ,  H01J49/0036 ,  H01J49/004

    摘要： The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum. The first form of the molecule includes a first combination of isotopes of one or more elements. The second form of the molecule includes a second combination of isotopes of the one or more elements. A first peak and a second peak that differ in mass by a multiple of a mass difference between the first combination of isotopes and the second combination of isotopes are located in the mass spectrum. The number of atoms of the one or more elements present in an ion of the molecule is identified from a mass difference between the first peak and the second peak.

    MODULATION OF INSTRUMENT RESOLUTION DEPENDANT UPON THE COMPLEXITY OF A PREVIOUS SCAN
    6.
    发明授权
    MODULATION OF INSTRUMENT RESOLUTION DEPENDANT UPON THE COMPLEXITY OF A PREVIOUS SCAN 有权

    公开(公告)号：EP2850644B1

    公开(公告)日：2018-10-31

    申请号：EP13790399.3

    申请日：2013-04-19

    申请人： DH Technologies Development Pte. Ltd.

    发明人： CAMPBELL, John, Lawrence ,  TATE, Stephen

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0081 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004

    摘要： Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample.

    DATA INDEPENDENT ACQUISITION OF PRODUCTION SPECTRA AND REFERENCE SPECTRA LIBRARY MATCHING
    7.
    发明公开
    DATA INDEPENDENT ACQUISITION OF PRODUCTION SPECTRA AND REFERENCE SPECTRA LIBRARY MATCHING 审中-公开
    日本麻省理工学院埃里克森·皮恩·伯恩

    公开(公告)号：EP2617052A2

    公开(公告)日：2013-07-24

    申请号：EP11778958.6

    申请日：2011-09-14

    申请人： DH Technologies Development Pte. Ltd. ,  ETH Zurich

    发明人： BONNER, Ronald ,  TATE, Stephen ,  AEBERSOLD, Rudolf ,  NAVARRO ALVAREZ, Pedro Jose ,  RINNER, Oliver ,  REITER, Lukas ,  GILLET, Ludovic

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0036 ,  G01N30/7233 ,  G06F19/703 ,  G06F19/709 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/42

    摘要： Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.

    摘要翻译： 公开了用于使用重叠的前体隔离窗分析样品的系统和方法。 指示串联质谱仪的质量分析器使用处理器在样品的前体离子质量范围内选择和分割至少两个重叠的前体隔离窗口。 串联质谱仪包括质量分析器，其允许在样品质量范围内重叠的前体隔离窗口。