公开(公告)号：EP2126060B1

公开(公告)日：2016-10-05

申请号：EP08717945.3

申请日：2008-03-18

申请人： DSM IP Assets B.V.

发明人： DIJK, VAN, Albertus, Alard ,  DEKKER, Petrus, Jacobus, Theodorus ,  WESTERLAKEN, Ilja ,  BAKHUIS, Janna Gardina

IPC分类号： C12N9/06 ,  C12P21/06 ,  C12P21/00 ,  A23J3/08 ,  A23J3/14 ,  A23J3/22

CPC分类号： A23J3/08 ,  A23J3/14 ,  A23J3/22 ,  A23L7/107 ,  A23L29/06 ,  C12N9/0022 ,  C12Y104/03013

公开(公告)号：EP2126060A1

公开(公告)日：2009-12-02

申请号：EP08717945.3

申请日：2008-03-18

申请人： DSM IP Assets B.V.

发明人： DIJK, VAN, Albertus, Alard ,  DEKKER, Petrus, Jacobus, Theodorus ,  WESTERLAKEN, Ilja ,  BAKHUIS, Janna Gardina

IPC分类号： C12N9/06 ,  C12P21/06 ,  A23L1/00 ,  C12P21/00

CPC分类号： A23J3/08 ,  A23J3/14 ,  A23J3/22 ,  A23L7/107 ,  A23L29/06 ,  C12N9/0022 ,  C12Y104/03013

摘要： The present invention relates to an isolated lysyl oxidase which is able to catalyze the oxidative deamination of lysyl groups in proteins or peptides to the corresponding aldehydes, with the subsequent reduction of O2 to H2O2 whereby the lysyl oxidase (a) shows a ratio of between lysyl oxidase activity for Ac-Gly-Lys-OMe and lysyl oxidase activity for benzylamine of at least 1.1, preferably at least 1.3, more preferably of at least 1.4 whereby the activities are determined at 37 degrees Celsius and an pH of 7.0; and. (b) has an optimum activity at a temperature of between 0 and 60 degrees Celcius.