-
公开(公告)号：EP3252074A1
公开(公告)日：2017-12-06
申请号：EP16743511.4
申请日：2016-01-29
发明人： KATAGIRI, Takenobu , OSAWA, Kenji , TSUKAMOTO, Sho , TSUJI, Shinnosuke , KAWAGUCHI, Yoshirou , NAKAMURA, Kensuke
IPC分类号： C07K16/28 , A61K39/395 , A61K45/00 , A61P19/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61P7/06 , A61P19/08 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： This application provides: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2; a method for producing the antibody; and a pharmaceutical composition comprising the antibody, for treating and/or preventing ectopic ossification and/or bone dysplasia, anemia, or diffuse intrinsic pontine glioma (DIPG).
摘要翻译： 本申请提供：特异性结合ALK2蛋白并具有抑制由ALK2介导的BMP信号转导活性的抗体; 生产抗体的方法; 以及包含该抗体的药物组合物，用于治疗和/或预防异位骨化和/或骨发育不良，贫血或弥散性内源脑桥胶质瘤（DIPG）。
-
公开(公告)号：EP3581651A1
公开(公告)日：2019-12-18
申请号：EP18750649.8
申请日：2018-02-06
发明人： CHAEN, Takashi , OHTSUKA, Toshiaki , IIDA, Kenji , NAKAMURA, Kensuke , ABURATANI, Takahide , ICHIKAWA, Junya , KUDO, Shota , PISCITELLI, Chayne Lee , SANCHES, Mario
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
摘要： [Problem to be Solved]
The present invention provides a novel antibody that binds to human GPRC5D, or a molecule having antigen binding activity, comprising the antibody.
[Solution]
The present invention provides a novel antibody that binds to human GPRC5D, a molecule having antigen binding activity, comprising the antibody, an anti-tumor pharmaceutical composition comprising the antibody or the molecule as an active ingredient, etc.-
公开(公告)号：EP4374852A3
公开(公告)日：2024-09-25
申请号：EP24164945.8
申请日：2018-05-14
IPC分类号： C12N15/13 , A61K9/00 , A61K31/4745 , A61K39/395 , A61K47/68 , A61P13/12 , A61P15/08 , A61P35/00 , A61P43/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , A61K9/08 , A61K9/19 , A61K39/00 , C12N5/16
CPC分类号： A61K31/4745 , A61P13/12 , A61P15/08 , A61P35/00 , C07K16/28 , A61K9/0019 , A61K9/08 , A61K47/26 , A61K47/10 , A61K9/0021 , A61K9/19 , C07K2317/7720130101 , C07K2317/3320130101 , C07K2317/2420130101 , C07K2317/9220130101 , C07K2317/7320130101 , A61K2039/50520130101 , C12N2510/0220130101 , C12N5/163 , C12N5/16 , A61K47/6849 , A61K47/6851 , A61K47/6861 , A61K47/6869 , A61K47/68033 , A61K47/68037
摘要： It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.
-
公开(公告)号：EP4374852A2
公开(公告)日：2024-05-29
申请号：EP24164945.8
申请日：2018-05-14
IPC分类号： A61K9/19
CPC分类号： A61K31/4745 , A61P13/12 , A61P15/08 , A61P35/00 , C07K16/28 , A61K9/0019 , A61K9/08 , A61K47/26 , A61K47/10 , A61K9/0021 , A61K9/19 , C07K2317/7720130101 , C07K2317/3320130101 , C07K2317/2420130101 , C07K2317/9220130101 , C07K2317/7320130101 , A61K2039/50520130101 , C12N2510/0220130101 , C12N5/163 , C12N5/16 , A61K47/6849 , A61K47/6851 , A61K47/6861 , A61K47/6869 , A61K47/68033 , A61K47/68037
摘要： It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.
-
公开(公告)号：EP3511414A1
公开(公告)日：2019-07-17
申请号：EP17848832.6
申请日：2017-09-07
IPC分类号： C12N15/09
摘要： To provide a novel antibody. Provided is a monoclonal antibody or a binding fragment thereof that binds to domain 3 of human LAG-3 and has one or more of the properties described in (ii) to (v), and the properties described in (i) and (vi) below: (i) having in vitro ADCC activity; (ii) reducing the number of LAG-3 positive cells in vivo in low fucose form; (iii) suppressing experimental autoimmune encephalomyelitis in vivo in low fucose form; (iv) binding to human activated T cells; (v) human LAG-3 binds to human major histocompatibility complex class II molecules in the presence of the antibody or the binding fragment thereof; and (vi) the presence of the antibody or the binding fragment thereof allowing human LAG-3 to exert a human T cell suppression function.
-
公开(公告)号：EP4166158A1
公开(公告)日：2023-04-19
申请号：EP21821552.3
申请日：2021-06-10
发明人： KAWAOKA, Yoshihiro , IMAI, Masaki , YAMAYOSHI, Seiya , ISHII, Ken , KOBIYAMA, Kouji , NAMBA, Eiko , OKA, Tatsuya , TOZUKA, Miyuki , JONAI, Nao , ONODERA, Yoshikuni , TAKESHITA, Fumihiko , SUZUKI, Takashi , NIWA, Takako , KOIZUMI, Makoto , NAKAMURA, Kensuke
IPC分类号： A61K39/00 , A61K39/215 , A61K48/00 , A61P31/12 , A61P31/14 , C07K14/165 , A61K9/107 , A61K9/14 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/28 , C12N15/50 , C12N15/88 , A61K31/7105
摘要： The present invention provides a vaccine for preventing and/or treating infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the S protein and/or a fragment thereof of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof
wherein R 1 and R 2 each independently represent a C 1 -C 3 alkyl group;
L 1 represents a C 17 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups;
L 2 represents a C 10 -C 19 alkyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups or a C 10 -C 19 alkenyl group which may have one or a plurality of C 2 -C 4 alkanoyloxy groups; and
p is 3 or 4.-
公开(公告)号：EP3323886B1
公开(公告)日：2020-10-21
申请号：EP16824539.7
申请日：2016-07-15
-
公开(公告)号：EP3561057A1
公开(公告)日：2019-10-30
申请号：EP17884717.4
申请日：2017-12-21
发明人： TAKAHASHI, Tohru , YOSHIMURA, Chigusa , KOZUMA, Shiho , NAKAMURA, Kensuke , SUZUKI, Chikako , ICHIKAWA, Junya
摘要： The present invention provides a novel antibody binding to human CD3, and a molecule having antigen binding activity that includes the antibody.
The present invention provides a novel antibody binding to human CD3, a molecule having antigen binding activity that includes the antibody, and a pharmaceutical composition having cytotoxic activity that includes the antibody or the molecule as an active ingredient.-
公开(公告)号：EP3805389A1
公开(公告)日：2021-04-14
申请号：EP19811934.9
申请日：2019-05-30
发明人： MIYAKE, Kensuke , MURAKAMI, Yusuke , MOTOI, Yuji , KANNO, Atsuo , SHIMIZU, Toshiyuki , OHTO, Umeharu , SHIMOZATO, Takaichi , MANNO, Atsushi , KAGARI, Takashi , ISHIGURO, Jun , NAKAMURA, Kensuke , ISOBE, Takashi
IPC分类号： C12N15/13 , A61K39/395 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/63 , C12P21/08
摘要： The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
-
公开(公告)号：EP3604518A1
公开(公告)日：2020-02-05
申请号：EP18776022.8
申请日：2018-03-29
IPC分类号： C12N15/06 , A61K39/395 , A61P1/04 , A61P35/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53
摘要： It is an object of the present invention to provide an anti-GPR20 antibody that can be used in the detection of GPR20, a reagent for GPR20 detection comprising the antibody, a reagent for diagnosis or a composition for testing of a disease related to the expression of GPR20, etc. The present invention provides an antibody specifically binding to a peptide comprising the amino acid sequence at amino acid positions 1 to 48 in SEQ ID NO: 1, or an antigen-binding fragment of the antibody, a chimeric antibody of the antibody, a rabbit type antibody of the antibody, etc. The present invention also provides a composition comprising the antibody, etc.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.017 秒)
