-
1.发明公开A SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER 审中-公开SIK抑制剂FOR USE IN一种用于治疗炎性和/或免疫疾病
公开(公告)号：EP2825160A1
公开(公告)日：2015-01-21
申请号：EP13711103.5
申请日：2013-03-13
IPC分类号： A61K31/00 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P29/00
CPC分类号： C07D239/48 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
摘要翻译： 本发明涉及这样的发现所做盐诱导激酶（植）抑制抗炎分子的形成：如IL-10，其是用于治疗炎症，并且识别SIK抑制剂的分辨率重要确实可以用于治疗与不期望的相关的病症 炎症,:如炎性肠疾病和/或自身免疫性疾病。
-
公开(公告)号：EP3265093A1
公开(公告)日：2018-01-10
申请号：EP16759581.8
申请日：2016-03-04
发明人： GRAY, Nathanael , ZHANG, Tinghu , HUANG, Hai-tsang , WANG, Yubao , ZHAO, Jean , CHOI, Hwan, Geun
IPC分类号： A61K31/535
CPC分类号： A61K31/337 , A61K31/4745 , A61K45/06 , A61P35/00 , C07D471/04 , C07D471/14 , A61K2300/00
摘要： Provided herein are tricyclic small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK). The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a tricyclic compound of the invention and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK.
-
公开(公告)号：EP3265072A1
公开(公告)日：2018-01-10
申请号：EP16759566.9
申请日：2016-03-04
发明人： GRAY, Nathanael , ZHANG, Tinghu , HUANG, Hai-Tsang , WANG, Yubao , ZHAO, Jean , CHOI, Hwan, Geun
IPC分类号： A61K31/155 , A61K31/165 , A61K31/166 , C07D205/04 , C07D211/08
CPC分类号： C07D403/12 , A61K31/337 , A61K31/55 , A61P35/00 , C07D223/16 , C07D231/12 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12
摘要： wherein X and R1-R3 are defined in the specification. The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK.
-
公开(公告)号：EP3778605A3
公开(公告)日：2021-03-10
申请号：EP20194167.1
申请日：2016-02-12
IPC分类号： C07D487/04 , C07D473/18 , A61K31/519 , A61P25/28
摘要： Compounds having the formula I, II, or III:
are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.-
公开(公告)号：EP3778604A1
公开(公告)日：2021-02-17
申请号：EP20194144.0
申请日：2016-02-12
IPC分类号： C07D487/04 , C07D473/18 , A61P25/28
摘要： Compounds having the formula I, II, or III:
are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.-
公开(公告)号：EP3256475A2
公开(公告)日：2017-12-20
申请号：EP16749958.1
申请日：2016-02-12
IPC分类号： C07D487/04 , C07D413/12 , C07D413/14 , C07D401/12 , C07D401/14 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), (II), (III) are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.
-
公开(公告)号：EP3481830A1
公开(公告)日：2019-05-15
申请号：EP17740232.8
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael, S. , LIANG, Yanke , CHOI, Hwan, Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
-
公开(公告)号：EP2825160B1
公开(公告)日：2018-10-03
申请号：EP13711103.5
申请日：2013-03-13
IPC分类号： A61K31/00 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P29/00
CPC分类号： C07D239/48 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
-
公开(公告)号：EP2970360A1
公开(公告)日：2016-01-20
申请号：EP14774148.2
申请日：2014-03-13
IPC分类号： C07H19/167 , A61K31/70
CPC分类号： C07H19/16 , A61K31/708 , A61K45/06 , C07F9/65616 , C07H19/167 , C07H19/20 , C07H19/207 , A61K2300/00
摘要： Described herein are compounds of Formulae (I)-(II), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., lung cancer, large bowel cancer, pancreas cancer, biliary tract cancer, or endometrial cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject.
摘要翻译： 本文描述的是式（I） - （II）的化合物及其药学上可接受的盐及其药物组合物。 还提供了涉及用于治疗或预防增殖性疾病如癌症（例如肺癌，大肠癌，胰腺癌，胆道癌或子宫内膜癌），良性肿瘤，血管生成，炎性疾病的本发明化合物或组合物的方法和试剂盒 ，自身炎症性疾病和自身免疫性疾病。
-
公开(公告)号：EP2440058A1
公开(公告)日：2012-04-18
申请号：EP10786967.9
申请日：2010-06-14
发明人： CHOI, Hwan, Geun , SIM, Taebo , GRAY, Nathanael , ZHOU, Wenjun , CHANG, Jae, Won , ZHANG, Jianming , WEISBERG, Ellen
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D513/04 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.022 秒)
