摘要:
Provided are improved fungal strains and use thereof, wherein the fungal strains are capable of producing an altered level of proteins, enzymes, variants and other substances of interest.
摘要:
The present compositions and methods relate to variant Ascomycetes sp. fungal cells that are genetically-modified to reduce the production of peptaibols, especially when grown on substrates containing insoluble material.
摘要:
The present teachings provide modified enzymes, preferably phytases, which have increased stability, hypothesized to arise from increased glycosylation. The enzymes can be modified to introduce or increase the number of glycosylation sites in the amino acid sequence, or glycosylation can be increased by the use of specific host production methods, or both. The enzymes of the present teachings have an increased stability after treatment at elevated temperature, which can be measured by inactivity reversibility or percent recovery following a treatment such as heating. The enzymes of the present teachings find application for example in food, feed, and feed pelleting.
摘要:
The application provides a method of reducing the DNA content of a protein preparation or a culture broth from a filamentous fungal host cell using an endogenous filamentous fungal host DNase activity.
摘要:
Described are compositions and methods relating variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g ., for the large-scale production of enzymes and other proteins for commercial applications.
摘要:
The invention provides methods for expression of a catalase enzyme in a Trichoderma host cell. In one embodiment, the catR gene from Aspergillus niger is expressed in Trichoderma reesei , resulting in improved yields of catalase enzyme in comparison with expression of catR in A. niger .
摘要:
The present compositions and methods relate to variant Ascomycetes sp. fungal cells that are genetically-modified to reduce the production of peptaibols, especially when grown on substrates containing insoluble material.