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1.发明授权KONJUGAT AUS ALBUMIN UND EINEM XANTHEN-FARBSTOFF ZUR UNTERSCHEIDUNG VON KRANKHAFTEM UND GESUNDEM GEWEBE 失效白蛋白偶联物和呫吨染料以示区别患病和健康组织
公开(公告)号：EP0877631B1
公开(公告)日：2003-04-16
申请号：EP97907031.5
申请日：1997-01-23
发明人： SINN, Hansjörg , MAIER-BORST, Wolfgang , STEHLE, Gerd , KAUS, Michael , WUNDER, Andreas , SCHRENK, Hans-Hermann , HOFF-BIEDERBECK, Dirk
IPC分类号： A61K49/00
CPC分类号： A61K49/0041 , A61K49/0043 , A61K49/0056 , G01N21/64 , G01N33/533
摘要： The invention relates to conjugates comprising a fluorescing compound, a linker and a protein. The invention also relates to the production of such conjugates and their use.
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公开(公告)号：EP0909182B1
公开(公告)日：2002-02-20
申请号：EP97931715.3
申请日：1997-07-04
CPC分类号： C07D487/22 , A61K41/0071
摘要： This invention concerns a method for production of chlorins and/or bacteriochlorins containing polyether, which consists of the following steps: (a) bonding a polyether to a porphyrin and (b) reacting the polyether-containing porphryin with a reducing agent. Furthermore, the invention concerns the polyether-containing chlorins and bacteriochlorins produced by the process and their use for photodynamic tumour therapy.
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公开(公告)号：EP0966427B1
公开(公告)日：2001-05-02
申请号：EP98912276.7
申请日：1998-02-18
IPC分类号： C07C231/02 , C07D487/22 , A61K49/00 , A61K47/48 , A61K47/22 , A61K47/30 , C07F15/00 , C07F17/02 , C07F5/06
CPC分类号： C07D487/22 , A61K47/60 , C07B43/06 , C07F9/4465 , C08G65/329 , C08G65/3332
摘要： A process is disclosed for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. Also disclosed is a process for metallising compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Also disclosed are the thus obtained products and their use for the therapy and/or diagnosis of tumours or inflammatory diseases.
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公开(公告)号：EP0952853A2
公开(公告)日：1999-11-03
申请号：EP96946222.0
申请日：1996-12-20
发明人： SINN, Hannsjörg , MAIER-BORST, Wolfgang , SCHRENK, Hans-Hermann , STEHLE, Gerd , FIEBIG, Heinz-H.
CPC分类号： A61K51/065 , A61K47/645 , A61K2121/00 , A61K2123/00
摘要： The present invention relates to conjugates comprising an active agent, a polypeptide and a polyether, a process for their production and their use.
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5.发明公开KONJUGAT AUS EINEM WIRKSTOFF, EINEM POLYETHER UND GGF. EINEM NICHT ALS KÖRPERFREMD ANGESEHENEN, NATIVEN PROTEIN 失效偶联物的活性物质，及聚醚MAY 一个没有身体对外久负盛名，天然蛋白质
公开(公告)号：EP0821593A2
公开(公告)日：1998-02-04
申请号：EP96909047.0
申请日：1996-04-12
CPC分类号： A61K49/0056 , A61K41/00 , A61K41/0071 , A61K47/62 , A61K49/0036 , A61K49/0054 , C07K14/765 , C08G65/329
摘要： The invention relates to a conjugate of an active agent, a polyether and possibly a native protein component regarded as acceptable by the body, in which the components are bonded via an acid amide and/or acid ester compound. The invention also relates to a process for producing such a conjugate and its use.
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公开(公告)号：EP0966427A1
公开(公告)日：1999-12-29
申请号：EP98912276.0
申请日：1998-02-18
IPC分类号： A61K31 , A61K41 , A61K47 , A61K49 , A61P29 , A61P35 , C07B43 , C07C231 , C07C237 , C07D487 , C07F3 , C07F9 , C08G65
CPC分类号： C07D487/22 , A61K47/60 , C07B43/06 , C07F9/4465 , C08G65/329 , C08G65/3332
摘要： A process is disclosed for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. Also disclosed is a process for metallising compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Also disclosed are the thus obtained products and their use for the therapy and/or diagnosis of tumours or inflammatory diseases.
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公开(公告)号：EP0909182A2
公开(公告)日：1999-04-21
申请号：EP97931715.0
申请日：1997-07-04
CPC分类号： C07D487/22 , A61K41/0071
摘要： This invention concerns a method for production of chlorins and/or bacteriochlorins containing polyether, which consists of the following steps: (a) bonding a polyether to a porphyrin and (b) reacting the polyether-containing porphryin with a reducing agent. Furthermore, the invention concerns the polyether-containing chlorins and bacteriochlorins produced by the process and their use for photodynamic tumour therapy.
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公开(公告)号：EP0877631A2
公开(公告)日：1998-11-18
申请号：EP97907031.0
申请日：1997-01-23
发明人： SINN, Hansjörg , MAIER-BORST, Wolfgang , STEHLE, Gerd , KAUS, Michael , WUNDER, Andreas , SCHRENK, Hans-Hermann
CPC分类号： A61K49/0041 , A61K49/0043 , A61K49/0056 , G01N21/64 , G01N33/533
摘要： The invention relates to conjugates comprising a fluorescing compound, a linker and a protein. The invention also relates to the production of such conjugates and their use.
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9.发明公开KONJUGAT AUS EINEM WIRKSTOFF UND EINEM NICHT ALS KÖRPERFREMD ANGESEHENEN, NATIVEN PROTEIN 失效缀合物的活性物质和没有外来的异文化久负盛名，天然蛋白质
公开(公告)号：EP0782456A1
公开(公告)日：1997-07-09
申请号：EP95932618.0
申请日：1995-09-22
发明人： SINN, Hansjörg , SCHRENK, Hans-Hermann , MAIER-BORST, Wolfgang , STEHLE, Gerd , WUNDER, Andreas , HOFF-BIEDERBECK, Dirk , HEENE, Dieter, Ludwig
CPC分类号： A61K41/0057 , A61K47/643
摘要： The invention concerns a conjugate consisting of an active substance and a native protein which is not considered exogenous. The conjugate is distinguished in that, between the active substance and the protein, there is a linker which can be cleaved in a cell. The invention further concerns a process for preparing such a conjugate and the use thereof.
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10.发明授权KONJUGAT AUS EINEM WIRKSTOFF, EINEM POLYETHER UND GGF. EINEM NICHT ALS KÖRPERFREMD ANGESEHENEN, NATIVEN PROTEIN 失效偶联物的活性物质，及聚醚MAY 一个没有身体对外久负盛名，天然蛋白质
公开(公告)号：EP0821593B1
公开(公告)日：2002-07-24
申请号：EP96909047.1
申请日：1996-04-12
CPC分类号： A61K49/0056 , A61K41/00 , A61K41/0071 , A61K47/62 , A61K49/0036 , A61K49/0054 , C07K14/765 , C08G65/329
摘要： The invention relates to a conjugate of an active agent, a polyether and possibly a native protein component regarded as acceptable by the body, in which the components are bonded via an acid amide and/or acid ester compound. The invention also relates to a process for producing such a conjugate and its use.
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