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公开(公告)号：EP0934430A1
公开(公告)日：1999-08-11
申请号：EP97912018.0
申请日：1997-09-25
发明人： DEBATIN, Klaus-Michael , LOS, Marek , HUG, Hubert
IPC分类号： C12Q1
CPC分类号： C12Q1/37 , G01N2333/96466
摘要： The invention relates to a method for apoptosis diagnosis in cells wherein the cells are loaded with a substrate for ICE/Ced3 family proteases and the protease reaction of the substrate is monitored by imaging methods. The invention also concerns a kit in order to carry out this method.
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公开(公告)号：EP0705278A1
公开(公告)日：1996-04-10
申请号：EP95909730.0
申请日：1995-02-16
发明人： KRAMMER, Peter , WESTENDORP, Michael , SCHULZE-OSTHOFF, Klaus , DEBATIN, Klaus-Michael , FRANK, Rainer , DHEIN, Jens , WALCZAK, Henning , KNIPPING, Eckart , STRICKER, Kirstin
IPC分类号： C12N15 , A61K38 , A61K39 , A61K45 , A61P31 , A61P43 , C07K14 , C07K16 , C07K19 , C12N9 , C12P21
CPC分类号： C07K16/2878 , A61K38/55 , A61K2039/505 , C07K14/70578 , C07K2317/54 , C07K2319/00 , C07K2319/30
摘要： The invention concerns an apoptose-inhibiting agent containing one, two or all of the following components: a) a compound which inhibits APO-1; b) a compound which inhibits or intercepts the APO-1 ligand; and c) a compound which inhibits the intra-cellular APO-1 signal path, the component(s) not being considered as foreign in an individual, plus the usual auxiliaries. The invention also concerns a compound, suitable for use in inhibiting apoptose, with at least one extra-cellular APO-1 domain and a carrier, the domain(s) and the carrier not being considered as foreign in an individual.
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公开(公告)号：EP0876503B1
公开(公告)日：2002-02-13
申请号：EP96946019.5
申请日：1996-11-27
CPC分类号： G01N33/5011
摘要： The invention relates to a process for determining the activity, in particular cytostatic activity, of drugs. Said process comprises the following steps: (a) incubation of the drugs with cells, and; (b) detecting the extent of apoptosis which is caused by the CD95/CD95 ligand system.
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公开(公告)号：EP0870061B1
公开(公告)日：2001-10-17
申请号：EP96945752.2
申请日：1996-11-27
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/158
摘要： The invention relates to a process for quantitative determination of CD95 ligand, comprising the following steps: (a) isolation of total RNA from cells; (b) transcription of total RNA from (a) into cDNA by reverse transcription and; (c) amplification of cDNA from (b) and a CD95 ligand competitor fragment by CD95 ligand specific primers in a PCR reaction. The process is also suitable for determining the extent and/or course of apoptosis.
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公开(公告)号：EP0876503A2
公开(公告)日：1998-11-11
申请号：EP96946019.0
申请日：1996-11-27
CPC分类号： G01N33/5011
摘要： The invention relates to a process for determining the activity, in particular cytostatic activity, of drugs. Said process comprises the following steps: (a) incubation of the drugs with cells, and; (b) detecting the extent of apoptosis which is caused by the CD95/CD95 ligand system.
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公开(公告)号：EP0705278B1
公开(公告)日：2003-11-26
申请号：EP95909730.4
申请日：1995-02-16
发明人： KRAMMER, Peter , WESTENDORP, Michael , SCHULZE-OSTHOFF, Klaus , DEBATIN, Klaus-Michael , FRANK, Rainer , DHEIN, Jens , WALCZAK, Henning , KNIPPING, Eckart , STRICKER, Kirstin
IPC分类号： C07K14/715 , C07K16/28 , C12N15/62 , A61K39/395 , A61K39/42 , A61K38/17 , A61K38/55 , A61K31/37 , A61K31/70
CPC分类号： C07K16/2878 , A61K38/55 , A61K2039/505 , C07K14/70578 , C07K2317/54 , C07K2319/00 , C07K2319/30
摘要： The invention concerns an apoptose-inhibiting agent containing one, two or all of the following components: a) a compound which inhibits APO-1; b) a compound which inhibits or intercepts the APO-1 ligand; and c) a compound which inhibits the intra-cellular APO-1 signal path, the component(s) not being considered as foreign in an individual, plus the usual auxiliaries. The invention also concerns a compound, suitable for use in inhibiting apoptose, with at least one extra-cellular APO-1 domain and a carrier, the domain(s) and the carrier not being considered as foreign in an individual.
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公开(公告)号：EP0934430B1
公开(公告)日：2001-12-12
申请号：EP97912018.5
申请日：1997-09-25
发明人： DEBATIN, Klaus-Michael , LOS, Marek , HUG, Hubert
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/96466
摘要： The invention relates to a method for apoptosis diagnosis in cells wherein the cells are loaded with a substrate for ICE/Ced3 family proteases and the protease reaction of the substrate is monitored by imaging methods. The invention also concerns a kit in order to carry out this method.
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公开(公告)号：EP0870061A2
公开(公告)日：1998-10-14
申请号：EP96945752.0
申请日：1996-11-27
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/158
摘要： The invention relates to a process for quantitative determination of CD95 ligand, comprising the following steps: (a) isolation of total RNA from cells; (b) transcription of total RNA from (a) into cDNA by reverse transcription and; (c) amplification of cDNA from (b) and a CD95 ligand competitor fragment by CD95 ligand specific primers in a PCR reaction. The process is also suitable for determining the extent and/or course of apoptosis.
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