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    CITED4 AS PROGNOSTIC MARKER IN OLIGODENDROGLIAL TUMORS
    5.
    发明公开
    CITED4 AS PROGNOSTIC MARKER IN OLIGODENDROGLIAL TUMORS 审中-公开
    引用4作为预测恶性胶原瘤的预测指标

    公开(公告)号：EP1954823A1

    公开(公告)日：2008-08-13

    申请号：EP06818908.3

    申请日：2006-11-29

    申请人： Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts

    发明人： TEWS, Björn ,  LICHTER, Peter ,  ROERIG, Peter ,  VON DEIMLING, Andreas ,  HAHN, Meinhard ,  REIFENBERGER, Guido ,  FELSBERG, Jörg ,  HARTMANN, Christian

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158

    摘要： The present invention provides novel (diagnostic) methods of detecting cancer of the central nervous system, preferably oligodendrogliomas, by detecting the presence of CITED4-nucleic acid sequences in a biological sample. The present invention furthermore provides a (diagnostic) method for determining the degree of methylation of the promoter region of the CITED4 gene in a biological sample. As a further embodiment, a method for gene-therapy suitable for treating or preventing cancers of the central nervous system, preferably oligodendrogliomas, is provided. Finally, nucleic acid sequences, amino acid sequences, vectors, pharmaceutical compositions and kits, suitable in these inventive methods are disclosed herewith.

    摘要翻译： 本发明提供了通过检测生物样品中CITED4-核酸序列的存在来检测中枢神经系统癌症，优选少突胶质细胞瘤的新（诊断）方法。 本发明还提供了用于确定生物样品中CITED4基因的启动子区的甲基化程度的（诊断）方法。 作为另一个实施方案，提供了适合于治疗或预防中枢神经系统癌症，优选少突胶质细胞瘤的基因治疗的方法。 最后，适合于这些发明方法的核酸序列，氨基酸序列，载体，药物组合物和试剂盒在此公开。

    MEANS AND METHODS FOR THE DETERMINATION OF (D)-2-HYDROXYGLUTARATE (D2HG) OR (D)-2-HYDROXYADIPIC ACID
    9.
    发明公开
    MEANS AND METHODS FOR THE DETERMINATION OF (D)-2-HYDROXYGLUTARATE (D2HG) OR (D)-2-HYDROXYADIPIC ACID 有权
    手段与方法用于确定（D）-2-羟基戊二酸（D2HG）

    公开(公告)号：EP2820145A1

    公开(公告)日：2015-01-07

    申请号：EP13709069.2

    申请日：2013-03-01

    申请人： Deutsches Krebsforschungszentrum ,  Ruprecht-Karls-Universität Heidelberg

    发明人： BALSS, Jörg ,  PUSCH, Stefan ,  VON DEIMLING, Andreas ,  BUCKEL, Wolfgang

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/32 ,  C12Q2326/00 ,  G01N33/57407 ,  G01N2333/904 ,  G01N2458/15 ,  G01N2800/046 ,  G01N2800/22 ,  G01N2800/28

    摘要： The present invention relates to a method for detecting (D)-2-hydroxyglutarate or (D)-2- hydroxyadipic acid in a sample, the method comprising the steps of: a) contacting a sample with a reagent mixture, wherein said reagent mixture comprises: (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state,(iii)an electron transfer agent, (iv)a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor; and b) detecting (D)-2-hydroxyglutarate or (D)-2- hydroxyadipic acid by measuring the production of the reduced state of the dye. The invention further pertains to a method for diagnosing and/or monitoring a (D)-2-hydroxy- glutarate-associated disease in a subject. Encompassed by the invention is also a method for diagnosing a mutation in an isocitrate dehydrogenase (IDH) gene or in a (D)-2- hydroxyglutarate (D2HG) dehydrogenase enzyme gene in a subject. In addition, the invention provides for a kit comprising (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state,(iii)an electron transfer agent, (iv)a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor.