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公开(公告)号：EP2170956B1
公开(公告)日：2014-10-22
申请号：EP08759230.9
申请日：2008-06-13
发明人： KELM, Daniela , ALTEVOGT, Peter , MOLDENHAUER, Gerhard , BREITLING, Frank , KRÜGER, Achim , BÄRREITER, Silke , LÜTTGAU, Sandra , MÖBIUS, Ulrich , LI, Yi , SEBENS, Susanne , SCHÄFER, Heiner
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
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公开(公告)号：EP2170956A2
公开(公告)日：2010-04-07
申请号：EP08759230.9
申请日：2008-06-13
发明人： GAST, Daniela , ALTEVOGT, Peter , MOLDENHAUER, Gerhard , BREITLING, Frank , KRÜGER, Achim , WOLTERINK, Silke , LÜTTGAU, Sandra , MÖBIUS, Ulrich , LI, Yi
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
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3.发明授权
公开(公告)号：EP1140977B1
公开(公告)日：2005-03-09
申请号：EP99965395.9
申请日：1999-12-14
申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts , Europäisches Laboratorium für Molekularbiologie
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428
摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 °C, preferably below 50 °C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 °C, preferably below 50 °C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.
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4.发明公开VERFAHREN UND VORRICHTUNG ZUR SYNTHESE UND ANALYSE VON TRÄGERGEBUNDENEN ARRAYS VON OLIGOMEREN, INSBESONDERE VON PRIMERPAAREN FÜR DIE PCR, SOWIE TRÄGER MIT OLIGOMEREN 审中-公开方法和设备综合和分析CARRIER低聚物载体结合阵列，用于PCR尤其是引物对和与低聚物
公开(公告)号：EP1289646A2
公开(公告)日：2003-03-12
申请号：EP01911417.2
申请日：2001-02-02
IPC分类号： B01J19/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00729 , C07B2200/11 , C12Q1/6837 , C40B40/06 , Y02P20/55 , C12Q2565/537
摘要： The aim of the invention is to synthesize a support-bound array of oligomers with free ends A, said oligomers having a temporary protecting group on the 5'-OH end of the oligomers and permanent protecting groups on the reactive side-groups. To this end, the temporary protecting group is removed from the end B after the combinatorial synthesis of the oligomers onto the support. The free ends B are cross-linked before the permanent protecting groups are removed and the covalent bonds of the synthesized oligomers on the support can be removed via the end A so that free ends A are formed and so that a part of the synthesized oligomers covalently binds to the support even when the free ends A have been removed from the support.
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公开(公告)号：EP0547200B1
公开(公告)日：1998-04-29
申请号：EP92914024.2
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/00 , C07K14/245 , C07K16/00 , C07K16/40 , C07K2319/00 , C07K2319/02 , C12N9/88 , C12N15/1037 , C12N15/64
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公开(公告)号：EP0547201B1
公开(公告)日：2001-03-21
申请号：EP92914199.2
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/005 , C07K16/00 , C07K16/40 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N15/1037 , C12N2795/10022 , C12N2795/10322
摘要： A phagemide has been constructed that expresses an antibody merged to coliphage pIII protein. The phagemide is suitable for selecting specific antibodies from large gene banks with small quantities of antigen. The antibody-pIII gene can be strongly repressed, so that it allows antibody banks to be amplified without the danger of deletion mutants predominating. After induction, large quantities of the merged protein may be expressed.
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公开(公告)号：EP0749487A1
公开(公告)日：1996-12-27
申请号：EP95911308.0
申请日：1995-03-07
发明人： SCHIRRMACHER, Volker , KHAZAIE, Khashayarsha , HAAS, Claudia , MOLDENHAUER, Gerd , LITTLE, Melvyn , DÜBEL, Stefan , BREITLING, Frank , KIPRIYANOV, Sergey , GOTTER, Stefanie , RODE, Hans-Jürgen
CPC分类号： A61K39/0011 , A61K2039/6056 , C07K16/1027 , C07K16/2818
摘要： The present invention relates to a bonding reagent characterized in that it comprises a first bonding component for a cell surface protein and a second bonding component for an effector cell molecule having a co-stimulatory effect. The invention further relates to a process for preparing the bonding reagent, and to a vaccine containing said bonding reagent.
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公开(公告)号：EP0547201A1
公开(公告)日：1993-06-23
申请号：EP92914199.0
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/005 , C07K16/00 , C07K16/40 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N15/1037 , C12N2795/10022 , C12N2795/10322
摘要： On a construit un phagémide qui exprime un anticorps fusionné avec une protéine pIII de coliphages. Le phagémide est utile pour sélectionner des anticorps spécifiques dans de grandes banques de gènes avec de petites quantités d'antigène. Le gène anticorps-pIII peut être fortement réprimé, de sorte qu'il permet d'amplifier des banques d'anticorps sans danger de prédominance de mutants par délétion. Après induction, on peut exprimer de grandes quantités de la protéine fusionnée.
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公开(公告)号：EP0547200A1
公开(公告)日：1993-06-23
申请号：EP92914024.0
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/00 , C07K14/245 , C07K16/00 , C07K16/40 , C07K2319/00 , C07K2319/02 , C12N9/88 , C12N15/1037 , C12N15/64
摘要： Un vecteur exprime une chaîne unique de domaines variables d'anticorps couplée à la lipoprotéine associée au peptidoglycane (LAP) d'E. coli. L'invention concerne en outre l'utilisation de ce vecteur et un procédé d'isolement de cellules produisant des anticorps spécifiques.
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