公开(公告)号：EP4111487A1

公开(公告)日：2023-01-04

申请号：EP21760271.3

申请日：2021-03-01

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  BILHORN, Robert

IPC分类号： H01J37/244 ,  G01T1/29 ,  H01J37/26 ,  H01L27/146 ,  H04N5/32

公开(公告)号：EP4333452A3

公开(公告)日：2024-05-15

申请号：EP24150794.6

申请日：2020-04-17

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  ROBERT BILHORN, Robert

IPC分类号： H01J37/28 ,  H01J37/244 ,  G01N23/2251 ,  H04N23/667 ,  H04N23/81 ,  H04N25/445 ,  H04N25/531

CPC分类号： H01J37/244 ,  H01J2237/244620130101 ,  H01J37/28 ,  H01J2237/244120130101 ,  G01N23/2251 ,  G01N2223/612620130101 ,  H01J2237/280220130101 ,  H04N23/81 ,  H04N23/667 ,  H04N25/445 ,  H04N25/531

摘要： The present disclosure relates to transmission electron microscopy for evaluation of biological matter. According to an embodiment, the present disclosure further relates to an apparatus for determining the structure and/or elemental composition of a sample using 4D STEM, comprising a direct bombardment detector operating with global shutter readout, processing circuitry configured to acquire images of bright-field disks using either a contiguous array or non-contiguous array of detector pixel elements, correct distortions in the images, align each image of the images based on a centroid of the bright-field disk, calculate a radial profile of the images, normalize the radial profiles by a scaling factor, calculate the rotationally-averaged edge profile of the bright-field disk, and determine elemental composition within the specimen based on the characteristics of the edge profile of the bright-field disk corresponding to each specimen location.

公开(公告)号：EP4209000A1

公开(公告)日：2023-07-12

申请号：EP21864866.5

申请日：2021-07-26

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  BILHORN, Robert

IPC分类号： H04N5/232 ,  H04N5/369 ,  G02B7/34

公开(公告)号：EP4333452A2

公开(公告)日：2024-03-06

申请号：EP24150794.6

申请日：2020-04-17

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  ROBERT BILHORN, Robert

IPC分类号： H04N25/531

摘要： The present disclosure relates to transmission electron microscopy for evaluation of biological matter. According to an embodiment, the present disclosure further relates to an apparatus for determining the structure and/or elemental composition of a sample using 4D STEM, comprising a direct bombardment detector operating with global shutter readout, processing circuitry configured to acquire images of bright-field disks using either a contiguous array or non-contiguous array of detector pixel elements, correct distortions in the images, align each image of the images based on a centroid of the bright-field disk, calculate a radial profile of the images, normalize the radial profiles by a scaling factor, calculate the rotationally-averaged edge profile of the bright-field disk, and determine elemental composition within the specimen based on the characteristics of the edge profile of the bright-field disk corresponding to each specimen location.

公开(公告)号：EP3956919A1

公开(公告)日：2022-02-23

申请号：EP20792121.4

申请日：2020-04-17

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  BILHORN, Robert

IPC分类号： H01J37/244 ,  G01N23/00 ,  G02B26/10 ,  H01J37/00 ,  H01J37/26

公开(公告)号：EP3956691A1

公开(公告)日：2022-02-23

申请号：EP20791905.1

申请日：2020-04-17

申请人： Direct Electron, LP

发明人： BAMMES, Benjamin ,  BILHORN, Robert

IPC分类号： G01T1/16 ,  G01T1/20 ,  H01J37/26