公开(公告)号：EP3199171A1

公开(公告)日：2017-08-02

申请号：EP15842648.6

申请日：2015-09-16

申请人： University-Industry Cooperation Group of Kyung Hee University ,  Dong-A St Co., Ltd.

发明人： KIM, Youngmi ,  OH, Myung Sook ,  HONG, Seon-Pyo ,  SOHN, Mi Won ,  JEONG, Jin Seok ,  JIANG, Hai Hua ,  KIM, Eunjin ,  RYU, Ja Young ,  CHO, Young Woong ,  Du, Xiao Fei ,  CHOI, Sang Zin ,  KIM, Jeong Soo ,  KIM, Byoung Moon

IPC分类号： A61K36/65 ,  A61K36/232 ,  A61K36/233 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K36/65 ,  A21D13/047 ,  A21D13/40 ,  A23L2/52 ,  A23L7/109 ,  A23L13/422 ,  A23L23/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/352 ,  A61K31/357 ,  A61K31/7048 ,  A61K36/232 ,  A61K36/233 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

摘要翻译： 本发明涉及用于治疗和预防退行性神经疾病的药物组合物，其含有作为活性成分的选自牡丹根皮，当归达胡萝卜根和柴胡根中的两种或更多种的混合物提取物，或 其一部分。 具体而言，本发明混合物的提取物对线粒体功能损伤具有恢复效果，对内质网应激具有缓解作用，并且同时具有对炎症反应的抑制效果，与体外显示的相比，其显着改善 单一提取物和混合物的提取物在帕金森病动物模型中显着地表现出对运动协调的改善效果和对多巴胺能神经元的保护作用，因此，本发明混合物的提取物或其部分可用作 用于治疗和预防退行性神经疾病的药物组合物的活性成分。

公开(公告)号：EP3235503A2

公开(公告)日：2017-10-25

申请号：EP15870222.5

申请日：2015-12-03

申请人： Dong-A ST Co., Ltd.

发明人： CHOI, Sang Zin ,  SOHN, Mi Won ,  GO, Hyo Sang ,  RYU, Ja Young ,  JEONG, Jin Seok ,  CHOI, Song Hyen ,  KIM, Eun Jin ,  CHO, Young Woong ,  KIM, So Young

IPC分类号： A61K36/605 ,  A61K36/076 ,  A23L33/10 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K36/076 ,  A61K36/605

摘要： The present invention relates to a composition comprising the mixed extract of mulberry and Poria cocos peel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry and Poria cocos peel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

摘要翻译： 本发明涉及包含桑树和茯苓皮的混合提取物用于预防，改善或治疗神经变性疾病的组合物。 作为本发明组合物中所含活性成分的桑树和茯苓皮的混合提取物通过抑制乙酰胆碱酯酶和通过抑制β淀粉状蛋白和τ磷酸化的形成而具有神经保护作用和神经元保护，具有记忆改善活性 并促进NGF的产生。 因此，本发明可用作用于预防或治疗退行性神经疾病的药物组合物，或用作上述目的的保健食品。

公开(公告)号：EP3199171B1

公开(公告)日：2018-12-26

申请号：EP15842648.6

申请日：2015-09-16

申请人： University-Industry Cooperation Group of Kyung Hee University ,  Dong-A St Co., Ltd.

发明人： KIM, Youngmi ,  OH, Myung Sook ,  HONG, Seon-Pyo ,  SOHN, Mi Won ,  JEONG, Jin Seok ,  JIANG, Hai Hua ,  KIM, Eunjin ,  RYU, Ja Young ,  CHO, Young Woong ,  Du, Xiao Fei ,  CHOI, Sang Zin ,  KIM, Jeong Soo ,  KIM, Byoung Moon

IPC分类号： A61K36/65 ,  A61K36/232 ,  A61K36/233 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K36/65 ,  A21D13/047 ,  A21D13/40 ,  A23L2/52 ,  A23L7/109 ,  A23L13/422 ,  A23L23/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/352 ,  A61K31/357 ,  A61K31/7048 ,  A61K36/232 ,  A61K36/233 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

公开(公告)号：EP3560506A1

公开(公告)日：2019-10-30

申请号：EP17883777.9

申请日：2017-12-20

申请人： Seoul National University Hospital ,  Dong-A ST Co., Ltd.

发明人： CHO, Young Woong ,  SON, Mi Won ,  CHOI, Sang Zin ,  CHOI, Song Hyen ,  JEONG, Jin Seok ,  SONG, In Sung ,  KIM, Nayoung

IPC分类号： A61K36/70 ,  A23L33/105

摘要： The present invention relates to a pharmaceutical composition comprising an Indigo Pulverata Levis extract or a fraction thereof as an effective ingredient for preventing or treating inflammatory bowel disease. Exhibiting the effect of reducing the activity and expression of inflammatory activation markers and alleviating the disease activity index of inflammatory bowel disease, an Indigo Pulverata Levis extract or a fraction thereof according to the present invention may be useful as an agent for preventing and treating inflammatory bowel disease.

公开(公告)号：EP3235502A2

公开(公告)日：2017-10-25

申请号：EP15870223.3

申请日：2015-12-03

申请人： Dong-A ST Co., Ltd.

发明人： CHOI, Sang Zin ,  SOHN, Mi Won ,  GO, Hyo Sang ,  RYU, Ja Young ,  JEONG, Jin Seok ,  CHOI, Song Hyen ,  KIM, Eun Jin ,  CHO, Young Woong ,  KIM, So Young

IPC分类号： A61K36/076 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00

摘要： The present invention relates to a pharmaceutical composition and a food composition for preventing or ameliorating degenerative neurological disease comprising Poria cocos peel extract for preventing, or treating neurodegenerative disorders. Poria cocos peel extract which is the active ingredients contained in the composition of the present invention, has a memory ameliorating activity through inhibiting of acetylcholine esterase and a neuroprotective effect and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

摘要翻译： 本发明涉及用于预防或缓解退行性神经疾病的药物组合物和食物组合物，其包含茯苓剥离提取物用于预防或治疗神经变性疾病。 作为本发明组合物中含有的活性成分的茯苓剥皮提取物通过抑制乙酰胆碱酯酶而具有记忆改善活性，并且通过抑制β淀粉状蛋白和τ磷酸化的形成并促进NGF产生而具有神经保护作用和神经元保护。 因此，本发明可用作用于预防或治疗退行性神经疾病的药物组合物，或用作上述目的的保健食品。