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1.发明授权SOLID DISPERSION COMPRISING A HIGHLY SUBSTITUTED HYDROXYALKYL METHYLCELLULOSE 有权FESTE散剂麻醉剂HOCHSUBSTITERERTER羟丙基甲基纤维素
公开(公告)号：EP2874607B1
公开(公告)日：2017-05-31
申请号：EP13740163.4
申请日：2013-07-12
发明人： GRASMAN, Nicholas S. , GUILLAUDEU, Steven J. , HALL, Mark, J. , SHRESTHA, Uma , ROSE, Maureen L. , PORTER, William W. , SPAULDING, Wesley J. , O'DONNELL, Kevin P. , ROGERS, True L.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/343 , A61K31/4166 , A61K31/58 , A61K9/48 , A61K47/38
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/4891 , A61K31/343 , A61K31/4166 , A61K31/58
摘要： A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.
摘要翻译： 在至少一种羟烷基甲基纤维素中的至少一种羟烷基甲基纤维素中含有至少一种活性成分的固体分散体，DS为1.0至2.7，MS为0.40至1.30，其中DS为甲氧基的取代度，MS为羟基烷氧基 组，可以通过挤出或喷雾干燥来生产。
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公开(公告)号：EP2552402A2
公开(公告)日：2013-02-06
申请号：EP11707305.6
申请日：2011-02-25
发明人： HALL, Mark , COPPENS, Karen , READ, Michael , SHRESTHA, Uma
IPC分类号： A61K9/00 , A61K9/70 , A61K47/34 , A61K45/06 , A61K31/167 , A61K31/522 , A61K47/10 , A61K47/26
CPC分类号： A61K31/522 , A61K9/0014 , A61K9/006 , A61K9/7007 , A61K31/167 , A61K47/10
摘要： High amounts of active ingredients, such as drugs, can be incorporated into a multilayer melt-extruded film which comprises i) one or more active ingredient layers produced from a melt-extruded polymer composition comprising a) a water-soluble polymer and b) an active ingredient; and ii) one or more removable protective layers which leave the active ingredient layer(s) substantially intact upon removal of the protective layer(s).
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3.发明公开
公开(公告)号：EP2874607A1
公开(公告)日：2015-05-27
申请号：EP13740163.4
申请日：2013-07-12
发明人： GRASMAN, Nicholas S. , GUILLAUDEU, Steven J. , HALL, Mark, J. , SHRESTHA, Uma , ROSE, Maureen L. , PORTER, William W. , SPAULDING, Wesley J. , O'DONNELL, Kevin P. , ROGERS, True L.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/343 , A61K31/415 , A61K31/58
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1652 , A61K9/4891 , A61K31/343 , A61K31/4166 , A61K31/58
摘要： A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.
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4.发明公开A PROCESS FOR PRODUCING A MELT-EXTRUDED FILM, AND MELT-EXTRUDED FILM 审中-公开VERFAHREN ZUR HERSTELLUNG EINER SCHMELZEXTRUDIERTEN FOLIE UND SCHMELZEXTRUDIERTE FOLIE
公开(公告)号：EP2555912A2
公开(公告)日：2013-02-13
申请号：EP11708364.2
申请日：2011-02-25
发明人： HALL, Mark , READ, Michael , SHRESTHA, Uma
CPC分类号： B29C47/0004 , A61K9/0056 , A61K9/7007 , B29C47/0021 , B29C55/00 , B29K2001/00 , B29K2023/06 , B29K2031/00 , B29K2033/08 , B29K2105/0035 , B29K2995/005 , B29K2995/0051 , B29K2995/0062 , B29L2007/008 , B32B27/08 , B32B27/18 , B32B27/28 , B32B27/285 , B32B27/30 , B32B27/306 , B32B27/308 , B32B37/153 , B32B2038/0028 , B32B2250/24 , B32B2270/00 , B32B2307/7166 , B32B2307/732 , B32B2535/00 , C08J5/18 , C08J2301/28 , C08J2371/02
摘要： A melt-extruded film is produced by a process which comprises the steps of blending a) a water-soluble polymer, b) an active ingredient, and c) optional additives and subjecting the blend to melt-extrusion to produce an extruded melt and drawing the extruded melt at a draw-down ratio of from 1.5 to 20 to a film of a thickness of at least 0.04 mm.
摘要翻译： 熔融挤出膜通过以下步骤制备，该方法包括以下步骤：a）水溶性聚合物，b）活性成分，和c）任选的添加剂，并使共混物熔融挤出以产生挤出的熔体和拉伸 挤出的熔体以1.5至20的拉伸比至厚度至少为0.04mm的膜。
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公开(公告)号：EP2552402B1
公开(公告)日：2016-11-23
申请号：EP11707305.6
申请日：2011-02-25
发明人： HALL, Mark , COPPENS, Karen , READ, Michael , SHRESTHA, Uma
IPC分类号： A61K9/00 , A61K9/70 , A61K47/34 , A61K45/06 , A61K31/167 , A61K31/522 , A61K47/10 , A61K47/26
CPC分类号： A61K31/522 , A61K9/0014 , A61K9/006 , A61K9/7007 , A61K31/167 , A61K47/10
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公开(公告)号：EP2553003A1
公开(公告)日：2013-02-06
申请号：EP11708138.0
申请日：2011-02-25
发明人： HALL, Mark , READ, Michael , SHRESTHA, Uma
CPC分类号： A61K31/192 , A61K9/0056 , C08J5/18 , C08J2301/26 , C08J2371/02
摘要： A mono-layer or multi-layer film wherein at least one of the layers has a thickness of at least 0.125 mm is produced from a melt-extruded polymer composition comprising a) a water-soluble polymer, b) an active ingredient and c) an adjuvant selected from the group consisting of mono- and disaccharides, sugar alcohols, low molecular weight water soluble polymers, and salts of cross-linked carboxymethylcellulose, with the proviso that the adjuvant c) is different from the water-soluble polymer a).
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