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1.发明公开AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN 失效AMIDINOINDOLE，AMIDINOAZOLE及其类似物Xa因子和凝血酶的抑制剂
公开(公告)号：EP0960102A1
公开(公告)日：1999-12-01
申请号：EP97933214.0
申请日：1997-06-30
发明人： DOMINGUEZ, Celia , HAN, Qi , DUFFY, Daniel, Emmett , PARK, Jeongsook, Maria , QUAN, Mimi, Lifen , ROSSI, Karen, Anita , WEXLER, Ruth, Richmond
IPC分类号： A61K31 , A61P7 , A61P43 , C07D209 , C07D231 , C07D235 , C07D307 , C07D333 , C07D401 , C07D403 , C07D405 , C07D471
CPC分类号： C07D333/58 , C07D209/18 , C07D231/56 , C07D235/06 , C07D307/79 , C07D401/06 , C07D401/12 , C07D403/12 , C07D463/06 , C07D471/04
摘要： The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W?1, W2, and W3¿ are selected from CH and N, provided that one of W?1 and W2¿ is C(C(=NH)NH¿2?) and at most two of W, W?1, W2, and W3¿ are N and one of J?a and Jb¿ is substituted by -(CH¿2?)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.
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公开(公告)号：EP0946508A1
公开(公告)日：1999-10-06
申请号：EP97952409.0
申请日：1997-12-15
发明人： PINTO, Donald, Joseph, Phillip , PRUITT, James, Russell , CACCIOLA, Joseph , FEVIG, John, Matthew , HAN, Qi , ORWAT, Michael, James , QUAN, Mimi, Lifen , ROSSI, Karen, Anita
IPC分类号： C07D409 , C07D413 , A61K31 , A61P7 , A61P43 , C07D207 , C07D231 , C07D233 , C07D249 , C07D257 , C07D401 , C07D403 , C07D417 , C07D521
CPC分类号： C07D257/04 , C07D207/34 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/40 , C07D231/42 , C07D233/56 , C07D233/90 , C07D249/06 , C07D249/08 , C07D249/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
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3.发明公开NITROGEN CONTAINING HETEROAROMATICS WITH ORTHO-SUBSTITUTED P1'S AS FACTOR XA INHIBITORS 审中-公开含氮杂环具有邻位取代的P1基团作为因子Xa抑制剂的
公开(公告)号：EP1042299A1
公开(公告)日：2000-10-11
申请号：EP98962082.8
申请日：1998-12-11
IPC分类号： C07D231/14 , A61K31/415 , A61K31/44 , A61K31/445 , C07D231/24 , C07D231/22 , C07D249/04 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/12
CPC分类号： C07D257/04 , C07D231/14 , C07D231/22 , C07D231/24 , C07D249/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of Formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho to G on E and may be CH2NH2, which are useful as inhibitors of factor Xa.
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4.发明公开N-(AMIDINOPHENYL)-N'-(SUBST.)-3H-2,4-BENZODIAZEPIN-3-ONE DERIVATIVES AS FACTOR XA INHIBITORS 失效N-（氨基苯基）-N' - （亚甲基）-3H-2,4-BENZODIAZEPIN-3-ON衍生物ALS FAKTOR XA抑制剂
公开(公告)号：EP0960104A1
公开(公告)日：1999-12-01
申请号：EP97921242.0
申请日：1997-04-17
发明人： MADUSKUIE, Thomas, Peter, Jr. , GALEMMO, Robert, Anthony, Jr. , DOMINGUEZ, Celia , QUAN, Mimi, Lifen , ROSSI, Karen, Anita , STOUTEN, Petrus, Fredericus, Wilhelmus , SUN, Jung, Hui , WELLS, Brian, Lloyd
CPC分类号： C07D401/04 , C07D243/04 , C07D401/14 , C07D409/14 , C07D413/04 , C07D417/14
摘要： The present application describes N-(amidinophenyl) cyclourea analogs of formula (I) which are useful as inhibitors of factor Xa.
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