公开(公告)号：EP0939757A1

公开(公告)日：1999-09-08

申请号：EP96944984.0

申请日：1996-12-18

申请人： Dupont Pharmaceuticals Company

发明人： JADHAV, Prabhakar, Kondaji ,  PETRAITIS, Joseph, James ,  BATT, Douglas, Guy

IPC分类号： C07D487 ,  A61K31 ,  A61P7 ,  A61P19 ,  A61P27 ,  A61P35 ,  A61P43 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D471

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to novel heterocycles including 3-[1-[3-(imidazolin-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)propionic acid, which are useful as antagonists of the αvβ3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiongenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.

公开(公告)号：EP0783486B1

公开(公告)日：1999-10-13

申请号：EP95933935.9

申请日：1995-09-26

申请人： Dupont Pharmaceuticals Company

发明人： BATT, Douglas, Guy ,  PINTO, Donald, Joseph, Phillip ,  ORWAT, Michael, James ,  PETRAITIS, Joseph, James ,  PITTS, William, John

IPC分类号： C07C317/14 ,  C07C311/15 ,  C07C317/22 ,  C07C317/24 ,  C07C317/36 ,  C07D213/52 ,  C07D213/70 ,  C07D215/12 ,  C07D295/08 ,  C07D333/18 ,  A61K31/10

CPC分类号： C07D207/33 ,  C07C311/15 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/36 ,  C07C2601/14 ,  C07D213/52 ,  C07D213/70 ,  C07D215/12 ,  C07D261/08 ,  C07D263/34 ,  C07D275/02 ,  C07D295/096 ,  C07D307/38 ,  C07D307/79 ,  C07D333/22 ,  C07D333/54

摘要： This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents. The class of compounds useful in this method of treatment is represented by formula (I).

摘要翻译： 本发明涉及作为前列腺素合成酶抑制剂的邻位取代的苯基化合物，包含这些化合物的药物组合物以及使用这些化合物作为抗炎和解热剂的方法。 在这种治疗方法中有用的一类化合物由下式I表示：（I）