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公开(公告)号：EP1386912A4
公开(公告)日：2006-02-01
申请号：EP02720534
申请日：2002-04-19
申请人： EISAI CO LTD
发明人： SUZUKI SHUICHI , KOTAKE MAKOTO , MIYAMOTO MITSUAKI , KAWAHARA TETSUYA , KAJIWARA AKIHARU , HISHINUMA IEHARU , OKANO KAZUO , MIYAZAWA SYUHEI , CLARK RICHARD , OZAKI FUMIHIRO , SATO NOBUAKI , SHINODA MASANOBU , KAMADA ATSUSHI , TSUKADA ITARU , MATSUURA FUMIYOSHI , NAOE YOSHIMITSU , TERAUCHI TARO , OOHASHI YOSHIAKI , ITO OSAMU , TANAKA HIROSHI
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00 , C07D207/273 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/407
CPC分类号： C07D209/44
摘要： A cyclic amidine derivative represented by the formula (I) or a salt thereof: (I) wherein R?1, R2, and R3¿ each represents hydrogen, C¿1-6? alkyl, C1-6 alkyl substituted by aryl, etc.; R?4, R5, and R7¿ each represents hydrogen, C¿1-6? alkyl, etc.; z is 0 or 1; R?6¿ represents hydrogen, C¿1-6? alkyl, (C1-6 alkyl)oxycarbonyl, etc.; n is 1 or 2; Y?1¿ represents a single bond, -CH¿2?-, etc.; Y?2¿ represents a single bond, -CO-, etc.; and Ar represents hydrogen, a group represented by the formula (II): (II) (wherein R?10 to R14¿ each represents hydrogen, C¿1-6? alkyl, hydroxy, C1-6 alkoxy, etc., provided that R?12¿ may be bonded to R?11 or R13¿ to form a 5- to 8-membered heterocycle), etc.
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公开(公告)号：EP1391456A4
公开(公告)日：2006-02-01
申请号：EP02718622
申请日：2002-04-19
申请人： EISAI CO LTD
发明人： SUZUKI SHUICHI , KOTAKE MAKOTO , MIYAMOTO MITSUAKI , KAWAHARA TETSUYA , KAJIWARA AKIHARU , HISHINUMA IEHARU , OKANO KAZUO , MIYAZAWA SYUHEI , CLARK RICHARD , OZAKI FUMIHIRO , SATO NOBUAKI , SHINODA MASANOBU , KAMADA ATSUSHI , TSUKADA ITARU , MATSUURA FUMIYOSHI , NAOE YOSHIMITSU , TERAUCHI TARO , OOHASHI YOSHIAKI , ITO OSAMU , TANAKA HIROSHI
IPC分类号： C07D233/88 , A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00
CPC分类号： C07D209/44
摘要： A 2-iminoimidazole derivative represented by the formula (I) or a salt thereof: (I) wherein R1, R2, and R3 each represents hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, -CH2-, etc.; Y2 represents a single bond, -CO-, etc.; and Ar represents hydrogen, a group represented by the formula (II): (II) (wherein R10 to R14 each represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, etc., provided that R12 may be bonded to R11 or R13 to form a 5- to 8-membered heterocycle), etc.
摘要翻译： 由式（I）表示的2-亚氨基咪唑衍生物或其盐：（I）其中R1，R2和R3各自代表氢，任选取代的C1-6烷基等; R6代表氢，C1-6烷基，C1-6烷氧基羰基等; Y1表示单键，-CH2-等; Y2表示单键，-CO-等; （II）表示的基团：其中R 10至R 14各自表示氢，C 1-6烷基，羟基，C 1-6烷氧基等，条件是R 12可以与R 11键合 或R13形成5至8元杂环）等。
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公开(公告)号：EP1391451A4
公开(公告)日：2006-02-01
申请号：EP02724628
申请日：2002-04-19
申请人： EISAI CO LTD
发明人： SUZUKI SHUICHI , KOTAKE MAKOTO , MIYAMOTO MITSUAKI , KAWAHARA TETSUYA , KAJIWARA AKIHARU , HISHINUMA IEHARU , OKANO KAZUO , MIYAZAWA SYUHEI , CLARK RICHARD , OZAKI FUMIHIRO , SATO NOBUAKI , SHINODA MASANOBU , KAMADA ATSUSHI , TSUKADA ITARU , MATSUURA FUMIYOSHI , NAOE YOSHIMITSU , TERAUCHI TARO , OOHASHI YOSHIAKI , ITO OSAMU , TANAKA HIROSHI
IPC分类号： C07D209/44 , A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00
CPC分类号： C07D209/44
摘要： 2-Iminopyrrolidine derivatives represented by the general formula (I) or salts thereof: (I) wherein B is a benzene or pyridine ring, or the like; R101 to R103 are each hydrogen, halogeno, C1-6 alkyl, or the like; R5 is hydrogen, C1-6 alkyl, C1-6 alkoxy C1-6 alkyl, or the like; R6 is hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, or the like; Y1 is a single bond, -CH2-, or the like; Y2 is a single bond, -CO-, or the like; and Ar is hydrogen, a group represented by the general formula (II): (II) (wherein R10 to R14 are each hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, or the like, or R11 and R12 or R12 and R13 may be united to form a 5- to 8-membered heterocycle), or the like.
摘要翻译： 由下式表示的2-亚氨基咪唑衍生物：其中R 1，R 2和R 3代表氢，任选取代的C 1-6烷基等; R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基，C 1-6烷氧基等，R 11和R 11 R 12或R 12和R 13可以键合在一起形成5-至8-元杂环或其盐。
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公开(公告)号：EP1394152A4
公开(公告)日：2005-02-02
申请号：EP02720536
申请日：2002-04-19
申请人： EISAI CO LTD
发明人： SUZUKI SHUICHI , KOTAKE MAKOTO , MIYAMOTO MITSUAKI , KAWAHARA TETSUYA , KAJIWARA AKIHARU , HISHINUMA IEHARU , OKANO KAZUO , MIYAZAWA SYUHEI , CLARK RICHARD , OZAKI FUMIHIRO , SATO NOBUAKI , SHINODA MASANOBU , KAMADA ATSUSHI , TSUKADA ITARU , MATSUURA FUMIYOSHI , NAOE YOSHIMITSU , TERAUCHI TARO , OOHASHI YOSHIAKI , ITO OSAMU , TANAKA HIROSHI
IPC分类号： A61K20060101 , A61K31/403 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/34 , C07D209/44 , C07D209/52 , C07D209/54 , C07D209/62 , C07D209/96 , C07D213/73 , C07D213/74 , C07D233/46 , C07D233/66 , C07D233/88 , C07D233/90 , C07D235/30 , C07D249/14 , C07D261/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D521/00
CPC分类号： C07D209/44
摘要： 2-Iminoimidazole derivatives represented by the general formula (I) or salts thereof: (I) wherein C is a benzene ring, a pyridine ring, or the like; R1 is optionally substituted C1-6 alkyl or the like; R201 is hydrogen, halogeno, acyl, or the like; R6 is hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, or the like; Y1 is a single bond, -CH2-, or the like; Y2 is a single bond, -CO-, or the like; and Ar is hydrogen, a group represented by the general formula (II): (II) (wherein R10 to R14 are each hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, or the like, or R11 and R12 or R12 and R13 may be united to form a 5- to 8-membered heterocycle), or the like.
摘要翻译： （I）表示的2-氨基咪唑衍生物或其盐：（I）其中C是苯环，吡啶环等; R1是任选取代的C1-6烷基等; R201是氢，卤代，酰基等; R6是氢，C1-6烷基，C1-6烷氧基羰基等; Y1是单键，-CH2-等; Y2是单键，-CO-等; （II）:(式中，R 10〜R 14分别为氢，C 1-6烷基，羟基，C 1-6烷氧基等，或R 11和R 12或R 12表示的基团， 和R13可以结合形成5至8元杂环）等。
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