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    Peptides which enhance transport across tissues
    1.
    发明公开
    Peptides which enhance transport across tissues 失效
    Peptiden die den TransportüberGewebenerhöhen

    公开(公告)号：EP1281718A2

    公开(公告)日：2003-02-05

    申请号：EP02021532.3

    申请日：1996-11-11

    申请人： ELAN CORPORATION, Plc ,  CYTOGEN CORPORATION

    发明人： O'Mahony, Daniel Joseph ,  Alvarez, Vernon Leon

    IPC分类号： C07K14/47

    CPC分类号： C12N15/1037 ,  C07K14/47 ,  C07K14/705 ,  C40B40/02 ,  G01N33/5088 ,  G01N33/56983

    摘要： A peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in s6itu to a site in an animal, such as into the gastro-intestinal tract. At a predetermined time, the phage which is transported across a tissue barrier is harvested at a harvesting site which is separated from the site of administration by the tissue barrier to select transported phage. This transported phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the site of administration to the harvesting site. The identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.

    摘要翻译： 允许或促进活性剂通过人或动物组织的运输的肽。 来自随机噬菌体文库或预选噬菌体文库的预定量的噬菌体在体内或在动物（例如进入胃肠道）的位点施用。 在预定时间内，跨越组织屏障传送的噬菌体在收集部位收获，该收获部位通过组织屏障与施用部位分离，以选择输送的噬菌体。 这种转运的噬菌体在宿主中被扩增。 重复这个事件循环（使用最近循环中产生的转运噬菌体）预定次数，以获得包含可以从施用部位运送到收获部位的噬菌体的选定噬菌体文库。 测定所选择的噬菌体文库中由噬菌体编码的至少一种肽的身份，以鉴定允许或促进活性剂通过人或动物组织的转运的肽。

    Peptides which enhance transport across tissues
    2.
    发明公开
    Peptides which enhance transport across tissues 失效
    肽增强跨组织运输

    公开(公告)号：EP1281718A3

    公开(公告)日：2005-01-19

    申请号：EP02021532.3

    申请日：1996-11-11

    申请人： ELAN CORPORATION, Plc ,  CYTOGEN CORPORATION

    发明人： O'Mahony, Daniel Joseph ,  Alvarez, Vernon Leon

    IPC分类号： G01N33/68 ,  C07K14/47 ,  C07K14/705

    CPC分类号： C12N15/1037 ,  C07K14/47 ,  C07K14/705 ,  C40B40/02 ,  G01N33/5088 ,  G01N33/56983

    摘要： A peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in s6itu to a site in an animal, such as into the gastro-intestinal tract. At a predetermined time, the phage which is transported across a tissue barrier is harvested at a harvesting site which is separated from the site of administration by the tissue barrier to select transported phage. This transported phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the site of administration to the harvesting site. The identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.