-
1.发明授权Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers 失效一种用于分离2-脱氧-2,2-二氟-D-呋喃核糖基烷基磺酸酯端基异构体的过程
公开(公告)号：EP0576232B1
公开(公告)日：1997-03-05
申请号：EP93304821.7
申请日：1993-06-21
-
公开(公告)号：EP0577304A1
公开(公告)日：1994-01-05
申请号：EP93304822.5
申请日：1993-06-21
发明人： Chou, Ta-Sen , Grossman, Cora Sue , Hertel, Larry Wayne , Holmes, Richard Elmer , Jones, Charles David , Mabry, Thomas Edward
CPC分类号： C07H19/04
摘要： A stereoselective anion glycosylation process for preparing β anomer enriched 2'-deoxy-2',2'-difluoronucleosides by reacting an αanomer enriched 2-deoxy-fluoro-1-halo carbohydrate with at least a molar equivalent of a nucleobase salt in an inert solvent.
摘要翻译： 通过使富含α-异构体的2-脱氧 - 氟-1-卤代碳水化合物与至少一摩尔当量的核碱基盐在惰性溶剂中反应来制备富含β'-端基异构体的2'-脱氧-2'，2'-二氟核苷的立体选择性阴离子糖基化方法 溶剂。
-
3.发明公开Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers 失效Verfahren zur Trennung von 2-Deoxy-2,2-二氟-D-呋喃核糖基 - 烷基磺酰胺 - 异恶唑。
公开(公告)号：EP0576232A1
公开(公告)日：1993-12-29
申请号：EP93304821.7
申请日：1993-06-21
摘要： A process for separating an anomeric mixture of alpha and beta 2-deoxy-2,2-difluoro-D-ribofuranosyl-1-alkylsulfonates by contacting the anomeric mixture with a solvent; heating; adding a countersolvent; and lowering the temperature.
摘要翻译： 通过使异头混合物与溶剂接触来分离α和β2-脱氧-2,2-二氟-D-呋喃核糖基-1-烷基磺酸酯的端基异构体混合物的方法; 加热; 增加一个反倾销 并降低温度。
-
公开(公告)号：EP0306190A3
公开(公告)日：1991-11-21
申请号：EP88307750.5
申请日：1988-08-22
IPC分类号： C07H7/027 , C07H13/08 , C07H19/073 , C07H19/04
CPC分类号： C07D307/33 , C07H19/06 , Y02P20/55
摘要： The present invention provides a process for preparing lactone intermediates to 2′,2′-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2′-deoxy-2′,2′-difluoronucleosides in about a 1:1 α/β anomeric ratio, and processes for selectively isolating β-2′-deoxy-2′,2′-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 α/β mixture.
-
5.发明授权
公开(公告)号：EP0113568B1
公开(公告)日：1990-04-04
申请号：EP83307675.5
申请日：1983-12-16
发明人： Chou, Ta-Sen , Heath, Perry Clark
IPC分类号： C07D501/46
CPC分类号： C07D501/46
-
公开(公告)号：EP0175544A2
公开(公告)日：1986-03-26
申请号：EP85306449.1
申请日：1985-09-11
IPC分类号： C07D501/18
CPC分类号： C07D501/04 , C07D501/18
摘要： 57 7β-Amino-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate dihydrochloride salt is obtained as the crystalline dihydrate directly from the N-deacylation reaction mixture by mixing said reaction mixture with acetonitrile, acetone or isopropyl alcohol, each containing 5% to 10% water.
摘要翻译： 通过将所述反应混合物与乙腈，丙酮或异丙醇各自混合，直接由N-脱酰反应混合物得到577β-氨基-3-（1-吡啶鎓甲基）-3-头孢烯-4-羧酸盐二盐酸盐作为结晶二水合物 含有5％至10％的水。
-
公开(公告)号：EP0015345A1
公开(公告)日：1980-09-17
申请号：EP79302931.5
申请日：1979-12-17
发明人： Chou, Ta-Sen
IPC分类号： C07D209/48 , C07D207/46 , C07D211/92
CPC分类号： C07D209/48 , C07D207/46 , C07D211/92
摘要： N-chlorophthalimide, N-chlorosuccinimide, and N-chloroglutarimide are prepared by contacting the corresponding imide with molecular chlorine under substantially non-aqueous conditions in an inert organic solvent in the presence of a polyvinylpyridine copolymer.
-
8.发明授权Process for purifying and isolating 2'-deoxy-2',2'-difluoronucleosides 失效用于分离和2'-脱氧-2的纯化2'-二氟核苷的方法”，
公开(公告)号：EP0712860B1
公开(公告)日：2001-12-05
申请号：EP95308034.8
申请日：1995-11-09
IPC分类号： C07H19/073 , C07H19/06
-
9.发明授权Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates 失效一种用于富集的β-异头2-脱氧-2,2-二氟-D-呋喃核糖基芳基磺酸盐的制造过程
公开(公告)号：EP0576228B1
公开(公告)日：1999-02-03
申请号：EP93304816.7
申请日：1993-06-21
发明人： Chou, Ta-Sen , Jones, Charles David
-
10.发明授权Low temperature process for preparing alpha-anomer enriched 2-deoxy-2, 2-difluoro-D-ribofuranosyl sulfonates 失效用于生产富集的α-端基异构体的2-脱氧-2,2-二氟-D-呋喃核糖基磺酸盐的低温过程
-
-
-
-
-
-
-
-
-
搜索结果
42 条记录 (耗时 0.014 秒)
