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1.发明授权SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES 有权具有抗病毒和抗微生物特性的取代的核苷衍生物
公开(公告)号：EP2175863B1
公开(公告)日：2018-03-21
申请号：EP08796131.4
申请日：2008-07-09
申请人： Eastern Virginia Medical School , Board of Governors for Higher Education, and State of Rhode Island Providence Plantations
IPC分类号： A61K31/7072
CPC分类号： C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
摘要： The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
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2.发明公开
公开(公告)号：EP2175863A2
公开(公告)日：2010-04-21
申请号：EP08796131.4
申请日：2008-07-09
IPC分类号： A61K31/7072
CPC分类号： C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
摘要： The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/ AIDS.
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