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1.发明公开
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公开(公告)号：EP3870167A2
公开(公告)日：2021-09-01
申请号：EP19877183.4
申请日：2019-10-23
发明人： SINGH, Onkar, N. , MCCORMICK, Timothy, J. , AGRAHARI, Vivek , PEET, Melissa , CLARK, Meredith, Roberts , SCHWARTZ, Jill , DONCEL, Gustavo, F.
IPC分类号： A61K31/34 , A61K31/427 , A61K31/513
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3.发明授权SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES 有权具有抗病毒和抗微生物特性的取代的核苷衍生物
公开(公告)号：EP2175863B1
公开(公告)日：2018-03-21
申请号：EP08796131.4
申请日：2008-07-09
申请人： Eastern Virginia Medical School , Board of Governors for Higher Education, and State of Rhode Island Providence Plantations
IPC分类号： A61K31/7072
CPC分类号： C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
摘要： The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
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4.发明公开
公开(公告)号：EP2175863A2
公开(公告)日：2010-04-21
申请号：EP08796131.4
申请日：2008-07-09
IPC分类号： A61K31/7072
CPC分类号： C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
摘要： The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/ AIDS.
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5.发明公开
公开(公告)号：EP1487432A2
公开(公告)日：2004-12-22
申请号：EP03721455.8
申请日：2003-03-26
发明人： DONCEL, Gustavo, F.
IPC分类号： A61K31/315
CPC分类号： A61K31/185 , A61K9/0031 , A61K9/0034 , A61K9/006 , A61K31/315 , Y02A50/463 , A61K2300/00
摘要： The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.
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6.发明授权
公开(公告)号：EP1487432B1
公开(公告)日：2013-03-06
申请号：EP03721455.8
申请日：2003-03-26
发明人： DONCEL, Gustavo, F.
IPC分类号： A61K31/315 , A61K31/185 , A61P15/18 , A61P31/00 , A61P31/02 , A61P31/12 , A61P31/10 , A61P31/04 , A61P33/00 , A61K9/00 , A61K45/06
CPC分类号： A61K31/185 , A61K9/0031 , A61K9/0034 , A61K9/006 , A61K31/315 , Y02A50/463 , A61K2300/00
摘要： The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.
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