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公开(公告)号：EP2528436A1
公开(公告)日：2012-12-05
申请号：EP11735350.8
申请日：2011-01-25
发明人： QIU, Yao-Ling , WANG, Ce , PENG, Xiaowen , YING, Lu , CAO, Hui , OR, Yat, Sun
IPC分类号： A01N43/00
CPC分类号： C07D498/18 , C07D519/00 , C07F9/6561
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B-W (I) which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：EP4247387A1
公开(公告)日：2023-09-27
申请号：EP21895733.0
申请日：2021-11-22
发明人： WANG, Guoqiang , SHEN, Ruichao , MA, Jun , HE, Yong , XING, Xuechao , CAO, Hui , GAO, Xuri , PENG, Xiaowen , PANARESE, Joseph, D. , OR, Yat, Sun
IPC分类号： A61K31/554 , A61P31/20 , C07D515/20
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公开(公告)号：EP3675637A1
公开(公告)日：2020-07-08
申请号：EP18852434.2
申请日：2018-08-28
发明人： QIU, Yao-ling , CAO, Hui , GAO, Xuri , KASS, Jordan , LI, Wei , PENG, Xiaowen , SUH, Byung-chul , OR, Yat, Sun
IPC分类号： A01N33/06 , A01N41/06 , A61K31/167
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公开(公告)号：EP2768517A2
公开(公告)日：2014-08-27
申请号：EP12842339.9
申请日：2012-10-17
发明人： QIU, Yao-ling , CAO, Hui , PENG, Xiaowen , CHEN, Zhigang , OR, Yat, Sun
IPC分类号： A61K38/12
CPC分类号： C07F9/65616 , A61K31/13 , A61K31/4188 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/21 , A61K38/55 , A61K45/06 , C07D498/08 , C07D498/18 , C07D519/00 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—Z—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-Z-W（I）。 因此，本发明化合物干扰丙型肝炎病毒的生命周期，并且也可用作抗病毒剂。 本发明进一步涉及包含前述化合物的药物组合物，用于给予患有HCV感染的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：EP4001279A1
公开(公告)日：2022-05-25
申请号：EP21209522.8
申请日：2021-11-22
发明人： WANG, Guoqiang , SHEN, Ruichao , HE, Yong , MA, Jun , XING, Xuechao , CAO, Hui , GAO, Xuri , PENG, Xiaowen , LONG, Jiang , Li, Wei , ZHANG, Jiajun , PANARESE, Joseph D. , KENTON, Nathaniel Thomas , BARTLETT, Samuel , OR, Yat Sun
IPC分类号： C07D471/04 , C07D487/10 , C07D519/00 , A61P31/14 , A61K31/407
摘要： The present invention discloses compounds of Formula ( Ia ), and pharmaceutically acceptable salts, thereof:
which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula ( Ia ) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula ( Ia ) or a pharmaceutically acceptable salt thereof.-
公开(公告)号：EP3468561A1
公开(公告)日：2019-04-17
申请号：EP17811015.1
申请日：2017-06-08
发明人： QIU, Yao-Ling , CAO, Hui , PENG, Xiaowen , LI, Wei , KASS, Jorden , GAO, Xuri , JIN, Meizhong , OR, Yat, Sun
IPC分类号： A61K31/519 , C07D239/20 , C07D487/04
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7.发明公开PROCESSES FOR THE PREPARATION OF 5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES 审中-公开用于生产-5-氮杂螺[2.4]庚烷-6-羧酸和它们的衍生物
公开(公告)号：EP2709455A2
公开(公告)日：2014-03-26
申请号：EP12786366.0
申请日：2012-05-17
发明人： QIU, Yao-Ling , PENG, Xiaowen , KIM, In, Jong , CAO, Hui , TANG, Datong , OR, Yat, Sun , WANG, Guoqiang , XU, Guoyou
IPC分类号： A01N53/00 , A61K31/215
CPC分类号： C07D209/54
摘要： The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (la), (lb) and (Ic):
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公开(公告)号：EP4376834A1
公开(公告)日：2024-06-05
申请号：EP22850031.0
申请日：2022-04-14
发明人： SHEN, Ruichao , HE, Yong , XING, Xuechao , RHODES, Matthew, C. , PANARESE, Joseph, D. , BARTLETT, Samuel , LI, Wei , CAO, Hui , ZHANG, Jiajun , PENG, Xiaowen , WANG, Guoqiang , OR, Yat, Sun
IPC分类号： A61K31/404 , C07D487/10 , A61P31/14
CPC分类号： C07D487/10 , A61P31/14 , C07D487/20 , C07D519/00
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公开(公告)号：EP3426245A1
公开(公告)日：2019-01-16
申请号：EP17763810.3
申请日：2017-03-06
发明人： QIU, Yao-Ling , GAO, Xuri , LI, Wei , CAO, Hui , JIN, Meizhong , KASS, Jorden , PENG, Xiaowen , OR, Yat, Sun
IPC分类号： A61K31/42 , A61K31/416 , C07D261/20
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公开(公告)号：EP2768825A2
公开(公告)日：2014-08-27
申请号：EP12842330.8
申请日：2012-10-17
发明人： TANG, Datong , XU, Guoyou , PENG, Xiaowen , YING, Lu , WANG, Ce , CAO, Hui , LONG, Jiang , KIM, In, Jong , WANG, Guoqiang , QIU, Yao-ling , OR, Yat, Sun
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):
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