公开(公告)号：EP4196117A1

公开(公告)日：2023-06-21

申请号：EP21856680.0

申请日：2021-08-12

申请人： Enanta Pharmaceuticals, Inc.

发明人： PANARESE, Joseph D. ,  DAVIS, Dexter ,  KENTON, Nathaniel Thomas ,  BARTLETT, Samuel ,  RAFFERTY, Sean M. ,  OR, Yat Sun

IPC分类号： A61K31/4155 ,  A61P31/00 ,  C07D207/27

公开(公告)号：EP4051265A1

公开(公告)日：2022-09-07

申请号：EP21846991.4

申请日：2021-07-19

申请人： Enanta Pharmaceuticals, Inc.

发明人： PANARESE, Joseph D. ,  DAVIS, Dexter ,  KENTON, Nathaniel Thomas ,  BARTLETT, Samuel ,  RAFFERTY, Sean ,  OR, Yat Sun

IPC分类号： A61K31/4155 ,  A61P31/00 ,  C07D207/27

公开(公告)号：EP4001279A1

公开(公告)日：2022-05-25

申请号：EP21209522.8

申请日：2021-11-22

申请人： Enanta Pharmaceuticals, Inc.

发明人： WANG, Guoqiang ,  SHEN, Ruichao ,  HE, Yong ,  MA, Jun ,  XING, Xuechao ,  CAO, Hui ,  GAO, Xuri ,  PENG, Xiaowen ,  LONG, Jiang ,  Li, Wei ,  ZHANG, Jiajun ,  PANARESE, Joseph D. ,  KENTON, Nathaniel Thomas ,  BARTLETT, Samuel ,  OR, Yat Sun

IPC分类号： C07D471/04 ,  C07D487/10 ,  C07D519/00 ,  A61P31/14 ,  A61K31/407

摘要： The present invention discloses compounds of Formula ( Ia ), and pharmaceutically acceptable salts, thereof:

which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula ( Ia ) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula ( Ia ) or a pharmaceutically acceptable salt thereof.