公开(公告)号：EP4376834A1

公开(公告)日：2024-06-05

申请号：EP22850031.0

申请日：2022-04-14

申请人： Enanta Pharmaceuticals, Inc.

发明人： SHEN, Ruichao ,  HE, Yong ,  XING, Xuechao ,  RHODES, Matthew, C. ,  PANARESE, Joseph, D. ,  BARTLETT, Samuel ,  LI, Wei ,  CAO, Hui ,  ZHANG, Jiajun ,  PENG, Xiaowen ,  WANG, Guoqiang ,  OR, Yat, Sun

IPC分类号： A61K31/404 ,  C07D487/10 ,  A61P31/14

CPC分类号： C07D487/10 ,  A61P31/14 ,  C07D487/20 ,  C07D519/00

公开(公告)号：EP3277286A1

公开(公告)日：2018-02-07

申请号：EP16774118.0

申请日：2016-03-30

申请人： Enanta Pharmaceuticals, Inc.

发明人： WANG, Guoqiang ,  OR, Yat Sun ,  SHEN, Ruichao ,  XING, Xuechao ,  LONG, Jiang ,  DAI, Peng ,  GRANGER, Brett ,  HE, Jing

IPC分类号： A61K31/575 ,  A61P1/16

CPC分类号： C07J43/003 ,  C07J9/00 ,  C07J9/005 ,  C07J41/005 ,  C07J41/0055 ,  C07J41/0088 ,  C07J51/00

摘要： The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

公开(公告)号：EP2429568B1

公开(公告)日：2016-08-17

申请号：EP10775229.7

申请日：2010-04-13

申请人： Enanta Pharmaceuticals, Inc.

发明人： GAI, Yonghua ,  OR, Yat Sun ,  WANG, Guoqiang

IPC分类号： A61K38/21 ,  A61K45/06 ,  C07K5/087 ,  C07K5/083 ,  C07K5/062

CPC分类号： A61K38/21 ,  A61K45/06 ,  C07K5/06034 ,  C07K5/0808 ,  C07K5/0812 ,  A61K2300/00

公开(公告)号：EP2768825A2

公开(公告)日：2014-08-27

申请号：EP12842330.8

申请日：2012-10-17

申请人： Enanta Pharmaceuticals, Inc.

发明人： TANG, Datong ,  XU, Guoyou ,  PENG, Xiaowen ,  YING, Lu ,  WANG, Ce ,  CAO, Hui ,  LONG, Jiang ,  KIM, In, Jong ,  WANG, Guoqiang ,  QIU, Yao-ling ,  OR, Yat, Sun

IPC分类号： C07D403/14

CPC分类号： C07D403/14

摘要： The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (I-a):

公开(公告)号：EP2618831A1

公开(公告)日：2013-07-31

申请号：EP11827336.6

申请日：2011-09-20

申请人： Enanta Pharmaceuticals, Inc.

发明人： OR, Yat Sun ,  MA, Jun ,  WANG, Guoqiang ,  LONG, Jiang ,  WANG, Bin

IPC分类号： A61K38/21

CPC分类号： C07K5/123 ,  A61K38/00 ,  A61K38/12 ,  A61K45/06 ,  C07K5/06034 ,  C07K5/0808 ,  C07K5/0823 ,  C07K5/0827 ,  C07K14/811

摘要： The present invention discloses compounds of Formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: Formula (I) which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：EP2203435A2

公开(公告)日：2010-07-07

申请号：EP08859833.9

申请日：2008-09-17

申请人： Enanta Pharmaceuticals, Inc.

发明人： KIM, In, Jong ,  LIU, Tongzhu ,  LONG, Jiang ,  WANG, Guoqiang ,  QUI, Yao-ling ,  KIM, Heejin ,  WANG, Yanchun ,  PHAN, Ly, Tam ,  OR, Yat, Sun

IPC分类号： C07D401/00

CPC分类号： C07H17/08 ,  C07D213/69 ,  C07D213/80 ,  C07D309/40 ,  C07D498/12

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：EP1506214A1

公开(公告)日：2005-02-16

申请号：EP03733983.5

申请日：2003-05-09

申请人： Enanta Pharmaceuticals, Inc.

发明人： OR, Yat, Sun ,  WANG, Guoqiang ,  PHAN, Ly, Tam ,  NIU, Deqiang ,  VO, Nha, Huu ,  QIU, Yao-Ling ,  WANG, Yanchun ,  BUSUYEK, Marina ,  HOU, Ying ,  PENG, Yulin ,  KIM, Heejin ,  LIU, Tongzhu ,  FARMER, Jay Judson ,  XU, Guoyou

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：EP4247387A1

公开(公告)日：2023-09-27

申请号：EP21895733.0

申请日：2021-11-22

申请人： Enanta Pharmaceuticals, Inc.

发明人： WANG, Guoqiang ,  SHEN, Ruichao ,  MA, Jun ,  HE, Yong ,  XING, Xuechao ,  CAO, Hui ,  GAO, Xuri ,  PENG, Xiaowen ,  PANARESE, Joseph, D. ,  OR, Yat, Sun

IPC分类号： A61K31/554 ,  A61P31/20 ,  C07D515/20

公开(公告)号：EP3787621A1

公开(公告)日：2021-03-10

申请号：EP19797015.5

申请日：2019-05-01

申请人： Enanta Pharmaceuticals, Inc.

发明人： WANG, Guoqiang ,  SHEN, Ruichao ,  GRANGER, Brett ,  HE, Jing ,  XING, Xuechao ,  HE, Yong ,  LONG, Jiang ,  MA, Jun ,  WANG, Bin ,  OR, Yat, Sun

IPC分类号： A61K31/4164 ,  A61K31/4196 ,  A61K31/4439

公开(公告)号：EP3548038A1

公开(公告)日：2019-10-09

申请号：EP17877352.9

申请日：2017-11-29

申请人： Enanta Pharmaceuticals, Inc.

发明人： WANG, Guoqiang ,  HE, Yong ,  DAI, Peng ,  XU, Guoyou ,  WANG, Bin ,  LONG, Jiang ,  OR, Yat, Sun

IPC分类号： A61K31/575 ,  C07C305/12