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公开(公告)号：EP3943485A1
公开(公告)日：2022-01-26
申请号：EP21175920.4
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3193606B1
公开(公告)日：2020-06-24
申请号：EP15840663.7
申请日：2015-09-09
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , FOLEY, Megan Alene Cloonan , KUNTZ, Kevin Wayne , MITCHELL, Lorna Helen , PETTER, Russell C. , SCHWARTZ, Carl Eric
IPC分类号： C07D261/18 , C07D413/12 , A61P35/00
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公开(公告)号：EP3193600A1
公开(公告)日：2017-07-26
申请号：EP15840789.0
申请日：2015-09-09
申请人： Epizyme, Inc.
发明人： FOLEY, Megan Alene Cloonan , KUNTZ, Kevin Wayne , MILLS, James Edward John , MITCHELL, Lorna Helen , MUNCHHOF, Michael John , HARVEY, Darren Martin
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D451/04 , C07C271/18 , C07D205/04 , C07D209/08 , C07D211/34 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/90 , C07D237/24 , C07D241/26 , C07D249/04 , C07D261/10 , C07D263/34 , C07D275/03 , C07D277/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/14
摘要： The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
摘要翻译： 本公开提供了具有式（I）的甲酰胺和磺酰胺：及其药学上可接受的盐和溶剂化物，其中A，Y，B，X和Z如说明书中所定义。 本公开还涉及式（I）化合物用于治疗对阻断SMYD蛋白例如SMYD3或SMYD2有响应的病症的用途。 本公开的化合物对于治疗癌症尤其有用。
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公开(公告)号：EP3184523B1
公开(公告)日：2019-06-19
申请号：EP16191716.6
申请日：2013-04-11
发明人： KUNTZ, Kevin Wayne , HUANG, Kuan-chun , CHOI, Hyeong Wook , SANDERS, Kristen , MATHIEU, Steven , CHANDA, Arani , FANG, Frank
IPC分类号： C07D405/12 , A61K31/5377 , A61P35/00 , A61P35/02
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公开(公告)号：EP4360712A2
公开(公告)日：2024-05-01
申请号：EP23217912.7
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： A61P35/00
CPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D405/14 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3486234A1
公开(公告)日：2019-05-22
申请号：EP18200713.8
申请日：2012-04-13
申请人： Epizyme Inc
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds (I) for use in treating a cell proliferative disorder.
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公开(公告)号：EP3470396A1
公开(公告)日：2019-04-17
申请号：EP18189032.8
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3165520B1
公开(公告)日：2018-08-15
申请号：EP16173275.5
申请日：2012-04-13
申请人： Epizyme Inc
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
CPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/048 , C07D491/08 , C07D491/10 , C07D491/113
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3193605A1
公开(公告)日：2017-07-26
申请号：EP15840497.0
申请日：2015-09-09
申请人： Epizyme, Inc.
发明人： MITCHELL, Lorna Helen , BELL, Andrew Simon , CHESWORTH, Richard , FOLEY, Megan Alene Cloonan , KUNTZ, Kevin Wayne , MILLS, James Edward John , MUNCHHOF, Michael John
IPC分类号： A01N43/80
CPC分类号： C07D451/04 , A61P35/00 , C07D413/12 , C07D413/14 , C07D487/08 , C07D519/00
摘要： The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
摘要翻译： 本公开提供了具有式（I）的取代的哌啶化合物及其药学上可接受的盐和溶剂合物，其中R 1，B，X和Z如说明书中所定义。 本公开还涉及式I化合物用于治疗响应于SMYD蛋白质例如SMYD3或SMYD2的阻断的病症的用途。 本公开的化合物对于治疗癌症尤其有用。
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公开(公告)号：EP3193603A1
公开(公告)日：2017-07-26
申请号：EP15839331.4
申请日：2015-09-09
申请人： Epizyme, Inc.
发明人： FOLEY, Megan Alene Cloonan , KUNTZ, Kevin Wayne , MILLS, James Edward John , MITCHELL, Lorna Helen , MUNCHHOF, Michael John , HARVEY, Darren Martin
IPC分类号： A01N43/80
CPC分类号： C07D413/12 , A61P35/00 , C07D261/18 , C07D413/14
摘要： The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
摘要翻译： 本公开提供了具有式（I）的取代的异恶唑甲酰胺化合物及其药学上可接受的盐和溶剂合物，其中R 1，R 2，A，X和Z如说明书中所定义。 本公开还涉及式I化合物用于治疗响应于SMYD蛋白质例如SMYD3或SMYD2的阻断的病症的用途。 本公开的化合物对于治疗癌症尤其有用。
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