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公开(公告)号：EP3943485A1
公开(公告)日：2022-01-26
申请号：EP21175920.4
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP2906537A2
公开(公告)日：2015-08-19
申请号：EP13846696.6
申请日：2013-10-15
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin, Wayne , CAMPBELL, John, Emmerson , SEKI, Masashi , SHIROTORI, Syuji , ITANO, Wataru , ZHENG, Wanjun
IPC分类号： C07D213/50 , C07D213/64 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP4360712A2
公开(公告)日：2024-05-01
申请号：EP23217912.7
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： A61P35/00
CPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D405/14 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP2906537B1
公开(公告)日：2020-03-11
申请号：EP13846696.6
申请日：2013-10-15
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin, Wayne , CAMPBELL, John, Emmerson , SEKI, Masashi , SHIROTORI, Syuji , ITANO, Wataru , ZHENG, Wanjun
IPC分类号： C07D213/50 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , A61K31/4412 , A61K31/444 , A61P35/00 , A61K31/4545 , A61K31/5375 , A61K31/5377 , C07D213/64 , C07D405/14
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公开(公告)号：EP3486234A1
公开(公告)日：2019-05-22
申请号：EP18200713.8
申请日：2012-04-13
申请人： Epizyme Inc
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds (I) for use in treating a cell proliferative disorder.
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公开(公告)号：EP3470396A1
公开(公告)日：2019-04-17
申请号：EP18189032.8
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3165520B1
公开(公告)日：2018-08-15
申请号：EP16173275.5
申请日：2012-04-13
申请人： Epizyme Inc
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
CPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/048 , C07D491/08 , C07D491/10 , C07D491/113
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP2697199B1
公开(公告)日：2016-06-08
申请号：EP12719529.5
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin, Wayne , CHESWORTH, Richard , DUNCAN, Kenneth, William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
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公开(公告)号：EP3725314A1
公开(公告)日：2020-10-21
申请号：EP20161557.2
申请日：2013-10-15
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin, Wayne , CAMPBELL, John, Emmerson , SEKI, Masashi , SHIROTORI, Syuji , ITANO, Wataru , ZHENG, Wanjun
IPC分类号： A61K31/5377 , C12Q1/68 , A61P35/00 , A61K31/4412 , A61K31/4545 , A61K31/5375 , A61P7/00 , A61P17/00 , A61P35/02 , A61P43/00 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：EP3628662A1
公开(公告)日：2020-04-01
申请号：EP19188699.3
申请日：2013-10-15
申请人： Epizyme, Inc.
IPC分类号： C07D213/50 , C07D401/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , A61K31/4412 , A61K31/444 , A61P35/00 , A61K31/4545 , A61K31/5375 , A61K31/5377 , C07D213/64 , C07D405/14
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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