公开(公告)号：EP1608373A2

公开(公告)日：2005-12-28

申请号：EP04757665.7

申请日：2004-03-19

申请人： Exelixis Inc.

发明人： PARKS, Jason Jevious ,  BANNEN, Lynne Canne ,  BROWN, S. David ,  CHENG, Wei ,  CHEUNG, Atwood Kim ,  DALRYMPLE, Lisa Esther ,  EPSHTEYN, Sergey ,  IBRAHIM, Mohamed Abdulkader ,  JAMMALAMADAKA, Vasu ,  LEAHY, James William ,  LEWIS, Gary Lee ,  MAC, Morrison B. ,  MANN, Larry W. ,  NUSS, John M. ,  NOGUCHI, Robin Tammie ,  RIDGWAY, Brian Hugh ,  SANGALANG, Joan C. ,  SCHNEPP, Kevin Luke ,  SHI, Xian ,  WILLIAMS, Matthew A. ,  XU, Wei ,  KHOURY, Richard

IPC分类号： A61K31/496 ,  C07D417/04 ,  C07D417/14

CPC分类号： A61K31/496 ,  C07D213/75 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.