公开(公告)号：EP1608373A2

公开(公告)日：2005-12-28

申请号：EP04757665.7

申请日：2004-03-19

申请人： Exelixis Inc.

发明人： PARKS, Jason Jevious ,  BANNEN, Lynne Canne ,  BROWN, S. David ,  CHENG, Wei ,  CHEUNG, Atwood Kim ,  DALRYMPLE, Lisa Esther ,  EPSHTEYN, Sergey ,  IBRAHIM, Mohamed Abdulkader ,  JAMMALAMADAKA, Vasu ,  LEAHY, James William ,  LEWIS, Gary Lee ,  MAC, Morrison B. ,  MANN, Larry W. ,  NUSS, John M. ,  NOGUCHI, Robin Tammie ,  RIDGWAY, Brian Hugh ,  SANGALANG, Joan C. ,  SCHNEPP, Kevin Luke ,  SHI, Xian ,  WILLIAMS, Matthew A. ,  XU, Wei ,  KHOURY, Richard

IPC分类号： A61K31/496 ,  C07D417/04 ,  C07D417/14

CPC分类号： A61K31/496 ,  C07D213/75 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

公开(公告)号：EP2134695A1

公开(公告)日：2009-12-23

申请号：EP08732145.1

申请日：2008-03-13

申请人： Exelixis, Inc.

发明人： BAHCECI, Suleyman ,  BAJJALIEH, William ,  CHEN, Jeff ,  EPSHTEYN, Sergey ,  FORSYTH, Timothy Patrick ,  HUYNH, Tai Phat ,  KIM, Byung Gyu ,  LEAHY, James W. ,  LEE, Matthew Sangyup ,  LEWIS, Gary L. ,  MAC, Morrison B. ,  MANN, Grace ,  MARLOWE, Charles K. ,  RIDGWAY, Brian Hugh ,  SANGALANG, Joan C. ,  SHI, Xian ,  TAKEUCHI, Craig Stacy ,  WANG, Yong ,  TESFAI, Zerom

IPC分类号： C07D239/42 ,  C07D401/04 ,  C07D403/12

CPC分类号： C07D239/42 ,  C07D239/70 ,  C07D239/84 ,  C07D239/95 ,  C07D401/04 ,  C07D403/12

摘要： The present invention is directed to a compound of Formula (I) or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula (I) to treat cancer.

公开(公告)号：EP1730128A1

公开(公告)日：2006-12-13

申请号：EP05733275.1

申请日：2005-03-31

申请人： Exelixis, Inc.

发明人： LEAHY, James William ,  LEWIS, Gary Lee ,  NUSS, John M. ,  RIDGWAY, Brian Hugh ,  SANGALANG, Joan C.

IPC分类号： C07D277/20

CPC分类号： C07D277/56 ,  C07D225/06 ,  C07D233/90 ,  C07D261/10 ,  C07D263/34 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

摘要： The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).