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公开(公告)号：EP1581309A2
公开(公告)日：2005-10-05
申请号：EP03812437.6
申请日：2003-11-14
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne, Canne , BROWN, S., David , CHENG, Wei , CO, Erick, Wang , NUSS, John, M. , KIM, Moon, Hwan , KLEIN, Rhett Ronald , LE, Donna, T. , LEW, Amy , MAC, Morrison, B. , PARKS, Jason Jevious , WEN,, Zhaoyang , XU, Wei
IPC分类号： A61P35/00 , A61K31/445 , A61K31/44 , A61K31/52 , A61K31/415 , A61K31/535 , C07D235/00 , C07D401/00 , C07D413/00 , C07D471/00 , C07D487/00
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D451/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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公开(公告)号：EP1608373A2
公开(公告)日：2005-12-28
申请号：EP04757665.7
申请日：2004-03-19
申请人： Exelixis Inc.
发明人： PARKS, Jason Jevious , BANNEN, Lynne Canne , BROWN, S. David , CHENG, Wei , CHEUNG, Atwood Kim , DALRYMPLE, Lisa Esther , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , JAMMALAMADAKA, Vasu , LEAHY, James William , LEWIS, Gary Lee , MAC, Morrison B. , MANN, Larry W. , NUSS, John M. , NOGUCHI, Robin Tammie , RIDGWAY, Brian Hugh , SANGALANG, Joan C. , SCHNEPP, Kevin Luke , SHI, Xian , WILLIAMS, Matthew A. , XU, Wei , KHOURY, Richard
IPC分类号： A61K31/496 , C07D417/04 , C07D417/14
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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公开(公告)号：EP1663204B1
公开(公告)日：2014-05-07
申请号：EP04782473.5
申请日：2004-08-27
申请人： Exelixis, Inc.
发明人： CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei , BAJJALIEH, William
IPC分类号： C07D257/04 , C07D403/04 , C07D215/14 , C07D401/12 , C07D403/12 , C07D239/26 , C07D405/12 , C07D409/12 , C07D241/12 , C07D417/12 , C07D249/06 , C07D471/04 , C07D261/08 , C07D207/333 , C07D209/12 , C07D213/30 , C07D307/42 , C07D307/91 , C07D207/404 , A61K31/41 , A61K31/495
CPC分类号： A61K31/41 , A61K31/495 , C07D207/333 , C07D207/404 , C07D209/12 , C07D213/30 , C07D215/14 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D261/08 , C07D307/42 , C07D307/91 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
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公开(公告)号：EP1678168B1
公开(公告)日：2012-07-11
申请号：EP04796443.2
申请日：2004-10-22
申请人： Exelixis, Inc.
发明人： CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei
IPC分类号： C07D413/00 , C07D251/48 , C07D239/02 , C07D213/84 , A61K31/535 , A01N43/66 , A01N43/54 , A01N43/40
CPC分类号： C07D239/58 , C07D213/85 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D417/12 , C07D487/04 , C07D491/04
摘要： The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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公开(公告)号：EP1663204A2
公开(公告)日：2006-06-07
申请号：EP04782473.5
申请日：2004-08-27
申请人： Exelixis, Inc.
发明人： CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei , BAJJALIEH, William
IPC分类号： A61K31/41 , A61K31/495 , C07D257/04 , C07D403/04
CPC分类号： A61K31/41 , A61K31/495 , C07D207/333 , C07D207/404 , C07D209/12 , C07D213/30 , C07D215/14 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D261/08 , C07D307/42 , C07D307/91 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.
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公开(公告)号：EP1678168A2
公开(公告)日：2006-07-12
申请号：EP04796443.2
申请日：2004-10-22
申请人： Exelixis, Inc.
发明人： CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei
IPC分类号： C07D413/00 , C07D251/48 , C07D239/02 , C07D213/84 , A61K31/535 , A01N43/66 , A01N43/54 , A01N43/40
CPC分类号： C07D239/58 , C07D213/85 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D417/12 , C07D487/04 , C07D491/04
摘要： The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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