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公开(公告)号：EP3329918A2
公开(公告)日：2018-06-06
申请号：EP17190013.7
申请日：2004-09-24
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
IPC分类号： A61K31/47 , A61P35/00 , C07D215/22 , A61K31/4709 , A61K31/517
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
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公开(公告)号：EP3329918A3
公开(公告)日：2018-08-15
申请号：EP17190013.7
申请日：2004-09-24
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
IPC分类号： A61K31/47 , A61P35/00 , C07D215/22 , A61K31/4709 , A61K31/517
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
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公开(公告)号：EP1673085B1
公开(公告)日：2011-11-09
申请号：EP04789057.9
申请日：2004-09-24
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
IPC分类号： C07D417/12 , A61K31/47 , A61K31/535 , C07D413/00 , C07D215/16 , C07D215/20 , C07D239/88 , C07D401/12 , A61P35/00
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides a compound which is represented by the following structure: which inhibits, regulates and/or modulates kinase receptors, particularly c-Met, KDR, c-Kit, flt-3 and flt-4. This compound is therefore suitable for the treatment of diseases or disorders associated with uncontrolled, abnormal and/or unwanted cellular activities.
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公开(公告)号：EP1673085A2
公开(公告)日：2006-06-28
申请号：EP04789057.9
申请日：2004-09-24
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
IPC分类号： A61K31/47 , A61K31/535 , C07D413/00 , C07D215/16 , C07D215/20
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides a compound which is represented by the following structure: which inhibits, regulates and/or modulates kinase receptors, particularly c-Met, KDR, c-Kit, flt-3 and flt-4. This compound is therefore suitable for the treatment of diseases or disorders associated with uncontrolled, abnormal and/or unwanted cellular activities.
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公开(公告)号：EP1773826A2
公开(公告)日：2007-04-18
申请号：EP05763620.1
申请日：2005-07-01
申请人： Exelixis, Inc.
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , DALRYMPLE, Lisa Esther , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , WANG, Yong , XU, Wei
IPC分类号： C07D417/04 , C07D487/04 , C07D473/06 , C07D473/10 , C07D473/22 , C07D473/24 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D491/04 , C07D495/04 , A61K31/52 , A61K31/522 , A61K31/519 , A61K31/437 , A61K31/4365 , A61K31/4355 , A61P35/00
CPC分类号： C07D487/04 , C07D209/52 , C07D471/04 , C07D473/30 , C07D473/32 , C07D493/04 , C07D493/14 , C07D493/20 , C07D498/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides appropriately functionalized 5,6-fused bicyclics which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, and flt-3, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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公开(公告)号：EP1608373A2
公开(公告)日：2005-12-28
申请号：EP04757665.7
申请日：2004-03-19
申请人： Exelixis Inc.
发明人： PARKS, Jason Jevious , BANNEN, Lynne Canne , BROWN, S. David , CHENG, Wei , CHEUNG, Atwood Kim , DALRYMPLE, Lisa Esther , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , JAMMALAMADAKA, Vasu , LEAHY, James William , LEWIS, Gary Lee , MAC, Morrison B. , MANN, Larry W. , NUSS, John M. , NOGUCHI, Robin Tammie , RIDGWAY, Brian Hugh , SANGALANG, Joan C. , SCHNEPP, Kevin Luke , SHI, Xian , WILLIAMS, Matthew A. , XU, Wei , KHOURY, Richard
IPC分类号： A61K31/496 , C07D417/04 , C07D417/14
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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