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公开(公告)号：EP1485390B1
公开(公告)日：2008-10-08
申请号：EP03743361.2
申请日：2003-02-28
IPC分类号： C07D495/04 , C07D487/04 , C07D491/04 , A61K31/519 , A61P19/02
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention discloses compounds corresponding to formula (I), wherein A, R, X, Y, R, R1 and R2 are as defined, pharmaceutical formulations, methods of making and uses thereof in the treatment of p38 kinase mediated diseases.
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公开(公告)号：EP1732918B1
公开(公告)日：2008-11-12
申请号：EP05716166.3
申请日：2005-03-17
发明人： ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HIMBER, Jacques , STAHL, Christoph, Martin , THOMI, Stefan
IPC分类号： C07D401/12 , C07D401/14 , C07D417/12 , C07D403/12 , C07D207/16 , A61K31/541 , A61P7/02
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP1567498B1
公开(公告)日：2008-01-23
申请号：EP03767602.0
申请日：2003-11-21
发明人： BANNER, David, William , GOBBI, Luca, Claudio , GROEBKE ZBINDEN, Katrin , OBST, Ulrike , STAHL, Christoph, Martin
IPC分类号： C07D213/56 , C07D213/65 , C07D213/30 , C07D271/06 , C07D239/42 , C07D213/38 , C07D213/73 , C07C257/18 , C07C259/18 , C07C243/38 , C07C271/66 , C07D211/46 , C07D309/12 , C07D265/36 , C07D295/14 , C07D521/00 , C07D311/04 , A61K31/155
CPC分类号： C07C257/18 , C07C259/18 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/65 , C07D213/73 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D265/36 , C07D271/06 , C07D295/15 , C07D309/12 , C07D311/04
摘要： The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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公开(公告)号：EP1689729A1
公开(公告)日：2006-08-16
申请号：EP04803221.3
申请日：2004-11-22
发明人： GODEL, Thierry , HILPERT, Hans , HUMM, Roland , ROGERS-EVANS, Mark , ROMBACH, Didier , STAHL, Christoph, Martin , WEISS, Peter , WOSTL, Wolfgang
IPC分类号： C07D307/60 , C07D405/06 , C07D409/06 , C07D207/38 , C07D495/06 , C07D403/06 , C07D401/06 , C07D417/06
CPC分类号： C07D401/06 , C07D207/38 , C07D307/60 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D495/06
摘要： This invention relates to new tetronic and tetramic acid derivatives with beta-secretase inhibitory activity of formula (I), wherein RI, R2, R3, R4, R5, R5', R6 and R6' areas defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of ß-secretase, such as Alzheimer's disease.
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公开(公告)号：EP1732918A1
公开(公告)日：2006-12-20
申请号：EP05716166.3
申请日：2005-03-17
发明人： ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HIMBER, Jacques , STAHL, Christoph, Martin , THOMI, Stefan
IPC分类号： C07D401/12 , C07D401/14 , C07D417/12 , C07D403/12 , C07D207/16 , A61K31/541 , A61P7/02
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型吡咯烷-3,4-二甲酰胺衍生物; 其中R1至R9和X如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa并可用作药物。
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公开(公告)号：EP1620408A2
公开(公告)日：2006-02-01
申请号：EP04726448.6
申请日：2004-04-08
发明人： DUNN, James, Patrick , GOLDSTEIN, David, Michael , STAHL, Christoph, Martin , TREJO-MARTIN, Teresa Alejandra
IPC分类号： C07D239/84 , C07D403/12 , C07D407/12 , A61K31/517 , A61P19/02
CPC分类号： C07D239/84 , C07D401/12 , C07D405/12
摘要： The present invention relates to compounds of formula (I), wherein R4, R5, R6, R7, Q, m and n are as defined in the specification. The compounds are useful as p38 kinase inhibitors, and therefore, may be used for treatment of p38-mediated disorder.
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公开(公告)号：EP1361880B1
公开(公告)日：2005-09-28
申请号：EP02726103.1
申请日：2002-02-04
发明人： CHEN, Jian, Jeffrey , DUNN, James, Patrick , GOLDSTEIN, David, Michael , STAHL, Christoph, Martin
IPC分类号： A61K31/519 , C07D471/04 , C07D519/00 , A61K31/4375 , A61P29/00 , A61P25/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides compounds of the Formula I and II, wherein R?1¨, R?3¨, W, Z, X?1¨, X?2¨, Ar?1¨, R?8¨ and R?9¨ are as defined herein, processes and intermediates for their preparation and their use for the treatment of p38 mediated disorders.
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公开(公告)号：EP1567498A2
公开(公告)日：2005-08-31
申请号：EP03767602.0
申请日：2003-11-21
发明人： BANNER, David, William , GOBBI, Luca, Claudio , GROEBKE ZBINDEN, Katrin , OBST, Ulrike , STAHL, Christoph, Martin
IPC分类号： C07D213/56 , C07D213/65 , C07D213/30 , C07D271/06 , C07D239/42 , C07D213/38 , C07D213/73 , C07C257/18 , C07C259/18 , C07C243/38 , C07C271/66 , C07D211/46 , C07D309/12 , C07D265/36 , C07D295/14 , C07D521/00 , C07D311/04 , A61K31/155
CPC分类号： C07C257/18 , C07C259/18 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/65 , C07D213/73 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D265/36 , C07D271/06 , C07D295/15 , C07D309/12 , C07D311/04
摘要： The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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公开(公告)号：EP1361880A2
公开(公告)日：2003-11-19
申请号：EP02726103.1
申请日：2002-02-04
发明人： CHEN, Jian, Jeffrey , DUNN, James, Patrick , GOLDSTEIN, David, Michael , STAHL, Christoph, Martin
IPC分类号： A61K31/519 , C07D471/04 , C07D519/00 , A61K31/4375 , A61P29/00 , A61P25/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides compounds of the Formula I and II, wherein R?1¨, R?3¨, W, Z, X?1¨, X?2¨, Ar?1¨, R?8¨ and R?9¨ are as defined herein, processes and intermediates for their preparation and their use for the treatment of p38 mediated disorders.
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