公开(公告)号：EP1401813A1

公开(公告)日：2004-03-31

申请号：EP02735394.5

申请日：2002-05-29

申请人： F. Hoffman-la Roche AG

发明人： BEARD, Colin, Charles ,  CLARK, Robin, Douglas ,  FISHER, Lawrence, Emerson ,  HARRIS, Ralph, New, III ,  REPKE, David, Bruce

IPC分类号： C07D209/30 ,  A61K31/496 ,  C07D403/04 ,  A61P25/00

CPC分类号： A61K31/405 ,  C07D209/30 ,  C07D401/04 ,  C07D401/12

摘要： This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I), wherein one of R?5, R6 or R7¿ is a group of general Formula (B), wherein W is a -CH-group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically aceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, Their use as therapeutic agents, and methods of preparation thereof.