公开(公告)号：EP1311475A1

公开(公告)日：2003-05-21

申请号：EP01974142.0

申请日：2001-08-08

申请人： F. HOFFMANN-LA ROCHE AG

发明人： ACKERMANN, Jean ,  AEBI, Johannes ,  BLUM, Denise ,  CHUCHOLOWSKI, Alexander ,  DEHMLOW, Henrietta ,  MAERKI, Hans-Peter ,  MORAND, Olivier ,  TRUSSARDI, Rene ,  VON DER MARK, Elisabeth ,  WALLBAUM, Sabine ,  WELLER, Thomas

IPC分类号： C07C311/20 ,  C07C311/07 ,  C07C271/24 ,  C07C271/56 ,  C07C275/26 ,  C07C335/14 ,  A61K31/135

CPC分类号： C07D295/088 ,  C07C233/23 ,  C07C233/74 ,  C07C235/54 ,  C07C235/84 ,  C07C255/57 ,  C07C271/52 ,  C07C271/56 ,  C07C275/26 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/38 ,  C07C275/40 ,  C07C291/04 ,  C07C307/08 ,  C07C307/10 ,  C07C311/07 ,  C07C311/13 ,  C07C311/20 ,  C07C335/14 ,  C07C335/16 ,  C07C335/18 ,  C07C335/22 ,  C07C2601/02 ,  C07C2601/14 ,  C07D295/135

摘要： The present invention relates to compounds of formula (I) wherein U, V, W, A?1, A2, A3, A4, A5, A6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

公开(公告)号：EP1303485A1

公开(公告)日：2003-04-23

申请号：EP01949485.5

申请日：2001-07-10

申请人： F. HOFFMANN-LA ROCHE AG

发明人： AEBI, Johannes ,  BLUM, Denise ,  BUR, Daniel ,  CHUCHOLOWSKI, Alexander ,  DEHMLOW, Henrietta ,  KITAS, Eric, Argirios ,  LOEFFLER, Bernd, Michael ,  OBST, Ulrike ,  WALLBAUM, Sabine

IPC分类号： C07D207/12 ,  C07D207/16 ,  C07D207/48 ,  C07D409/12 ,  C07D403/12 ,  C07D401/06 ,  A61K31/40 ,  A61P9/10 ,  A61P9/12 ,  A61P39/06

CPC分类号： C07D401/12 ,  C07D207/12 ,  C07D207/16 ,  C07D207/48 ,  C07D403/12 ,  C07D413/12

摘要： The present invention relates to compounds of formula (I), wherein R1, R2, A, X and m are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors or metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

公开(公告)号：EP1311475B1

公开(公告)日：2008-08-06

申请号：EP01974142.0

申请日：2001-08-08

申请人： F. Hoffmann-La Roche AG

发明人： ACKERMANN, Jean ,  AEBI, Johannes ,  BLUM, Denise ,  CHUCHOLOWSKI, Alexander ,  DEHMLOW, Henrietta ,  MAERKI, Hans-Peter ,  MORAND, Olivier ,  TRUSSARDI, Rene ,  VON DER MARK, Elisabeth ,  WALLBAUM, Sabine ,  WELLER, Thomas

IPC分类号： C07C311/20 ,  C07C311/07 ,  C07C271/24 ,  C07C271/56 ,  C07C275/26 ,  C07C335/14 ,  A61K31/135

CPC分类号： C07D295/088 ,  C07C233/23 ,  C07C233/74 ,  C07C235/54 ,  C07C235/84 ,  C07C255/57 ,  C07C271/52 ,  C07C271/56 ,  C07C275/26 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/38 ,  C07C275/40 ,  C07C291/04 ,  C07C307/08 ,  C07C307/10 ,  C07C311/07 ,  C07C311/13 ,  C07C311/20 ,  C07C335/14 ,  C07C335/16 ,  C07C335/18 ,  C07C335/22 ,  C07C2601/02 ,  C07C2601/14 ,  C07D295/135

摘要： The present invention relates to compounds of formula (I) wherein U, V, W, A?1, A2, A3, A4, A5, A6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。