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1.发明授权PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS 有权哌啶衍生物用作2,3-环氧角鲨烯羊毛甾醇环化酶抑制剂的
公开(公告)号：EP1317432B1
公开(公告)日：2008-01-16
申请号：EP01965225.4
申请日：2001-08-29
发明人： ACKERMANN, Jean , AEBI, Johannes , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , MORAND, Olivier , WALLABAUM, Sabine , WELLER, Thomas
IPC分类号： C07D211/44 , C07D211/22 , C07D401/12 , C07D417/12 , C07D211/26 , A61K31/445 , A61P3/06
CPC分类号： C07D211/46 , C07D211/22 , C07D211/26 , C07D211/96
摘要： The present invention relates to compound of formula (I), wherein U, V, W, A?1, A2, A3, A4, A5¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1667962A1
公开(公告)日：2006-06-14
申请号：EP04765119.5
申请日：2004-09-13
发明人： ACKERMANN, Jean , AEBI, Johannes , DEHMLOW, Henrietta , HIRTH, Georges , MAERKI, Hans-Peter , MORAND, Olivier , PANDAY, Narendra
IPC分类号： C07C311/20 , C07C271/24 , C07D239/42 , C07D403/12 , A61P9/10 , A61K31/18 , A61K31/325
CPC分类号： C07D239/26 , C07C271/56 , C07C311/20 , C07C2601/14 , C07D239/30 , C07D295/185 , C07D403/12
摘要： The present invention relates to compounds of formula (I); wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3，R 4，R 4， R 5，U，V，W，k和m如说明书和权利要求书及其药学上可接受的盐和/或其药学上可接受的酯所定义。 这些化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：EP1334094A1
公开(公告)日：2003-08-13
申请号：EP01982445.7
申请日：2001-10-26
IPC分类号： C07D333/54 , C07D275/04 , C07D409/12 , C07D417/12 , A61K31/381 , A61P3/00
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4¿, V, X, Y, Z, Q, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1311475B1
公开(公告)日：2008-08-06
申请号：EP01974142.0
申请日：2001-08-08
发明人： ACKERMANN, Jean , AEBI, Johannes , BLUM, Denise , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , MAERKI, Hans-Peter , MORAND, Olivier , TRUSSARDI, Rene , VON DER MARK, Elisabeth , WALLBAUM, Sabine , WELLER, Thomas
IPC分类号： C07C311/20 , C07C311/07 , C07C271/24 , C07C271/56 , C07C275/26 , C07C335/14 , A61K31/135
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to compounds of formula (I) wherein U, V, W, A?1, A2, A3, A4, A5, A6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：EP1358162B1
公开(公告)日：2006-02-08
申请号：EP01271362.4
申请日：2001-12-12
发明人： AEBI, Johannes , ACKERMANN, Jean , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , MORAND, Olivier , WALLBAUM, Sabine , WELLER, Thomas , PANDAY, Narendra
IPC分类号： C07D215/58 , C07D215/20 , C07D209/08 , A61K31/47 , A61K31/404
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4, A4¿, L, V, W, X, m and n are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3,-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperprolilerative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1334094B1
公开(公告)日：2004-12-29
申请号：EP01982445.7
申请日：2001-10-26
IPC分类号： C07D333/54 , C07D275/04 , C07D409/12 , C07D417/12 , A61K31/381 , A61P3/00
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4¿, V, X, Y, Z, Q, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1349833A1
公开(公告)日：2003-10-08
申请号：EP01994697.9
申请日：2001-11-21
发明人： ACKERMANN, Jean , AEBI, Johannes , DEHMLOW, Henrietta , MORAND, Olivier , PANDAY, Narendra , WELLER, Thomas
IPC分类号： C07D209/08 , C07D401/12 , C07D417/12 , C07D403/12 , A61K31/404 , A61K31/425 , A61K31/506 , A61K31/4439
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D417/12
摘要： The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4, A5, A6, A7¿, L, V, X, n and the bond ===== between the carbon atom Ca and the carbon atom Cb are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hyper cholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1303503B1
公开(公告)日：2010-01-27
申请号：EP01969367.0
申请日：2001-07-11
发明人： ACKERMANN, Jean , AEBI, Johannes , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , MORAND, Olivier , WALLBAUM, Sabine , WELLER, Thomas
IPC分类号： C07D295/08 , C07C311/21 , C07D211/70 , C07D211/46 , C07C311/29 , C07C275/34 , C07C271/28 , C07C335/18 , A61K31/16 , A61K31/33
CPC分类号： C07D213/75 , C07C233/29 , C07C233/75 , C07C235/56 , C07C235/84 , C07C255/57 , C07C271/28 , C07C271/58 , C07C275/34 , C07C275/38 , C07C307/10 , C07C311/13 , C07C311/21 , C07C311/29 , C07C323/44 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07D207/14 , C07D207/20 , C07D209/42 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D239/42 , C07D261/10 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/24 , C07D333/34 , C07D333/38
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemmia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中U，Y，V，W，L，X，A 1，A 2，A 3，A 4，A 5和A <6>如描述和权利要求及其药学上可接受的盐和/或其药学上可接受的酯所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病相关的疾病， 和/或治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：EP1456171A1
公开(公告)日：2004-09-15
申请号：EP02791779.8
申请日：2002-12-05
发明人： ACKERMANN, Jean , AEBI, Johannes , DEHMLOW, Henrietta , HIRTH, Georges , MAERKI, Hans-Peter , MORAND, Olivier
IPC分类号： C07C311/18 , C07C271/52 , C07D295/12 , C07D211/46 , C07D203/12 , C07C311/17 , C07C271/48 , C07D295/10 , C07D207/08 , C07D233/52 , C07D239/42 , C07C291/04 , A61K31/18 , A61K31/325 , A61P9/10
CPC分类号： C07D207/08 , C07C271/52 , C07C311/17 , C07C311/18 , C07C2601/14 , C07D205/04 , C07D211/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/084 , C07D295/088 , C07D295/135
摘要： The present invention relates to compounds of formula (I) wherein A?1, A2, A3, A4, A5, A6, A7, A8, A9, A10¿, U, V, W, m, n and p are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：EP1358162A1
公开(公告)日：2003-11-05
申请号：EP01271362.4
申请日：2001-12-12
发明人： AEBI, Johannes , ACKERMANN, Jean , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , MORAND, Olivier , WALLBAUM, Sabine , WELLER, Thomas , PANDAY, Narendra
IPC分类号： C07D215/58 , C07D215/20 , C07D209/08 , A61K31/47 , A61K31/404
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4, A4¿, L, V, W, X, m and n are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3,-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperprolilerative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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