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公开(公告)号：EP1999114A2
公开(公告)日：2008-12-10
申请号：EP07726783.9
申请日：2007-03-12
发明人： ANDERSON, Kevin William , FOTOUHI, Nader , GILLESPIE, Paul , GOODNOW, Robert Alan Jr. , GUERTIN, Kevin Richard , HAYNES, Nancy-Ellen , MYERS, Michael Paul , PIETRANICO-COLE, Sherrie Lynn , QI, Lida , ROSSMAN, Pamela Loreen , SCOTT, Nathan Robert , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , ZHANG, Qiang
IPC分类号： C07D231/12 , C07D403/04 , C07D231/16 , C07D231/38 , C07D401/04 , C07D413/04 , C07D417/04 , C07D407/14
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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2.发明授权DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USEFUL AS INHIBITORS FOR CDK2 AND ANGIOGESIS, AND FOR THE TREATMENT OF BREAST, COLON, LUNG AND PROSTATE CANCER 有权AS CDK2和血管生成抑制剂和用于乳腺癌，结肠癌，肺癌和前列腺SUITABLE二取代PYRAZOLOBENZODIAZEPINE于治疗
公开(公告)号：EP1802625B1
公开(公告)日：2008-06-18
申请号：EP05792946.5
申请日：2005-10-04
发明人： LIU, Jin-Jun , LUK, Kin-Chun , PIZZOLATO, Giacomo , REN, Yi , THAKKAR, Kshitij Chhabilbhai , WOVKULICH, Peter, Michael , ZHANG, Zhuming
IPC分类号： C07D487/04 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of the formula (I) wherein R1, R2, R3 and R4 are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
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公开(公告)号：EP1919878A1
公开(公告)日：2008-05-14
申请号：EP06792493.6
申请日：2006-07-11
发明人： HAYNES, Nancy-Ellen , KERTESZ, Denis John , PIETRANICO-COLE, Sherrie Lynn , QIAN, Yimin , SCOTT, Nathan Robert , SO, Sung-Sau , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright
IPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12 , A61K31/501 , A61P5/16
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
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公开(公告)号：EP1999114B1
公开(公告)日：2015-07-22
申请号：EP07726783.9
申请日：2007-03-12
发明人： Dr.ANDERSON, Kevin William , FOTOUHI, Nader , GILLESPIE, Paul , GOODNOW, Robert Alan Jr. , GUERTIN, Kevin Richard , HAYNES, Nancy-Ellen , MYERS, Michael Paul , PIETRANICO-COLE, Sherrie Lynn , QI, Lida , ROSSMAN, Pamela Loreen , SCOTT, Nathan Robert , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , ZHANG, Qiang
IPC分类号： C07D231/12 , C07D403/04 , C07D231/16 , C07D231/38 , C07D401/04 , C07D413/04 , C07D417/04 , C07D407/14
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
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公开(公告)号：EP1919878B1
公开(公告)日：2010-09-08
申请号：EP06792493.6
申请日：2006-07-11
发明人： HAYNES, Nancy-Ellen , KERTESZ, Denis John , PIETRANICO-COLE, Sherrie Lynn , QIAN, Yimin , SCOTT, Nathan Robert , SO, Sung-Sau , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright
IPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12 , A61K31/501 , A61P5/16
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
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公开(公告)号：EP2346807A1
公开(公告)日：2011-07-27
申请号：EP09748339.0
申请日：2009-11-09
发明人： FIROOZNIA, Fariborz , GILLESPIE, Paul , LIN, Tai-An , MERTZ, Eric , SIDDURI, Achyutharao , SO, Sung-Sau , TAN, Jenny , THAKKAR, Kshitij Chhabilbhai
IPC分类号： C07C57/58 , C07C69/78 , C07C231/12 , C07C255/57 , C07C311/16 , C07C317/24 , C07D231/12 , C07D257/04 , C07D317/70 , C07D295/26 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/36 , A61P11/06
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R
1 -R
6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在具体实施方式和权利要求书中定义。 另外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是CRTH2受体的拮抗剂或部分激动剂，并可用于治疗与该受体相关的疾病和病症如哮喘。
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