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公开(公告)号：EP1987019B1
公开(公告)日：2012-11-28
申请号：EP07704416.2
申请日：2007-02-07
发明人： GOBBI, Luca , JAESCHKE, Georg , LUEBBERS, Thomas , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , STEWARD, Lucinda
IPC分类号： C07D401/06 , C07D413/06 , C07D417/06 , C07C211/32 , A61K31/505 , A61P25/18
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
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2.发明授权
公开(公告)号：EP1828134B1
公开(公告)日：2008-10-29
申请号：EP05822659.8
申请日：2005-12-07
IPC分类号： C07D213/74 , C07D213/75 , C07D213/76 , A61K31/496 , A61P3/04
CPC分类号： C07D213/74 , C07D213/75 , C07D213/76
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment an /or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1532132B1
公开(公告)日：2008-03-19
申请号：EP03766236.8
申请日：2003-07-18
发明人： ALANINE, Alexander , BLEICHER, Konrad , GUBA, Wolfgang , HAAP, Wolfgang , KUBER, Dagmar , LUEBBERS, Thomas , PLANCHER, Jean-Marc , ROGERS-EVANS, Mark , SCHNEIDER, Gisbert , ZUEGGE, Jochen , ROCHE, Olivier
IPC分类号： C07D317/62 , C07D405/12 , C07D317/54 , C07D451/06 , A61K31/36
CPC分类号： C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
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公开(公告)号：EP1532132A1
公开(公告)日：2005-05-25
申请号：EP03766236.8
申请日：2003-07-18
发明人： ALANINE, Alexander , BLEICHER, Konrad , GUBA, Wolfgang , HAAP, Wolfgang , KUBE, Dagmar , LUEBBERS, Thomas , PLANCHER, Jean-Marc , ROGERS-EVANS, Mark , SCHNEIDER, Gisbert , ZUEGGE, Jochen , ROCHE, Olivier
IPC分类号： C07D317/62 , C07D405/12 , C07D317/54 , C07D451/06 , A61K31/36
CPC分类号： C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和X如说明书和权利要求书中所定义。 这些化合物可用于治疗和/或预防与CB1受体调节有关的疾病。
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5.发明授权1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967B1
公开(公告)日：2011-04-27
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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6.发明授权
公开(公告)号：EP1971605B1
公开(公告)日：2010-05-12
申请号：EP06830424.5
申请日：2006-12-06
IPC分类号： C07D471/04 , A61K31/4353 , A61P3/06 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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7.发明公开1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967A1
公开(公告)日：2008-09-17
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1966199A1
公开(公告)日：2008-09-10
申请号：EP06829951.0
申请日：2006-11-08
IPC分类号： C07D471/04 , A61K31/4453 , A61K31/4462 , A61K31/4465 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1957479A2
公开(公告)日：2008-08-20
申请号：EP06830046.6
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RUNTZ-SCHMITT, Valerie , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/4439 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1755593B1
公开(公告)日：2008-01-16
申请号：EP05775021.8
申请日：2005-05-24
发明人： GATTI McARTHUR, Silvia , HERTEL, Cornelia , NETTEKOVEN, Matthias, Heinrich , PLANCHER, Jean-Marc , RAAB, Susanne , ROCHE, Olivier , RODRIGUEZ-SARMIENTO, Rosa Maria , SCHULER, Franz
IPC分类号： A61K31/435 , A61P3/04 , C07D203/18 , C07D217/06 , C07D223/04 , C07D295/08 , C07D295/18
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula (I) wherein A, R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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