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公开(公告)号：EP1755593A1
公开(公告)日：2007-02-28
申请号：EP05775021.8
申请日：2005-05-24
发明人： GATTI McARTHUR, Silvia , HERTEL, Cornelia , NETTEKOVEN, Matthias, Heinrich , PLANCHER, Jean-Marc , RAAB, Susanne , ROCHE, Olivier , RODRIGUEZ-SARMIENTO, Rosa Maria , SCHULER, Franz
IPC分类号： A61K31/435 , A61P3/04 , C07D203/18 , C07D217/06 , C07D223/04 , C07D295/08 , C07D295/18
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula (I) wherein A, R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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2.发明授权5-METHOXY-8-ARYL-¬1,2,4|TRIAZOLO¬1,5-A|PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS 有权5-甲氧基-8-芳基 - ¬1,2,4|TRIAZOLO¬1,5-A |吡啶衍生物AS腺苷受体拮抗剂
公开(公告)号：EP1436292B1
公开(公告)日：2006-08-30
申请号：EP02777254.0
申请日：2002-09-28
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P25/16 , A61P25/24
CPC分类号： C07D471/04
摘要： The present application relates to compounds of the formula (I) wherein R1 is hydrogen, halogen or lower alkoxy; R2 is hydrogen or is C(O)- lower alkyl or -C(0)-phenyl, wherein the phenyl ring is unsubstituted or substituted by one or two substituents, selected from the group, consisting of halogen, lower alkoxy or trifluoromethyl, or is -C(O)-furanyl or -C(O)- thiophenyl, wherein the rings are unsubstituted or substituted by halogen; and to their pharmaceutically acceptable salts. The compounds may be used in the treatment of diseases associated with the adenosine A2 receptor.
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3.发明授权
公开(公告)号：EP1828134B1
公开(公告)日：2008-10-29
申请号：EP05822659.8
申请日：2005-12-07
IPC分类号： C07D213/74 , C07D213/75 , C07D213/76 , A61K31/496 , A61P3/04
CPC分类号： C07D213/74 , C07D213/75 , C07D213/76
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment an /or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1761519B1
公开(公告)日：2008-05-07
申请号：EP05756581.4
申请日：2005-06-13
发明人： GATTI MCARTHUR, Silvia , HERTEL, Cornelia , NETTEKOVEN, Matthias, Heinrich , RAAB, Susanne , ROCHE, Olivier , RODRIGUEZ-SARMIENTO, Rosa, Maria , SCHULER, Franz , PLANCHER, Jean-Marc
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D209/42 , A61K31/4439 , A61P3/04
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1761519A1
公开(公告)日：2007-03-14
申请号：EP05756581.4
申请日：2005-06-13
发明人： GATTI MCARTHUR, Silvia , HERTEL, Cornelia , NETTEKOVEN, Matthias, Heinrich , RAAB, Susanne , ROCHE, Olivier , RODRIGUEZ-SARMIENTO, Rosa, Maria , SCHULER, Franz , PLANCHER, Jean-Marc
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D209/42 , A61K31/4439 , A61P3/04
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1480976A1
公开(公告)日：2004-12-01
申请号：EP03742945.3
申请日：2003-02-19
发明人： MATTEI, Patrizio , NEIDHART, Werner , NETTEKOVEN, Matthias, Heinrich , PFLIEGER, Philippe , TAYLOR, Sven
IPC分类号： C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14 , A61K31/425
CPC分类号： C07D417/06 , C07D277/42
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
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7.发明公开
公开(公告)号：EP1828134A1
公开(公告)日：2007-09-05
申请号：EP05822659.8
申请日：2005-12-07
IPC分类号： C07D213/74 , C07D213/75 , C07D213/76 , A61K31/496 , A61P3/04
CPC分类号： C07D213/74 , C07D213/75 , C07D213/76
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment an /or prevention of diseases which are associated with the modulation of H3 receptors.
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8.发明公开5-METHOXY-8-ARYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS 有权5-甲氧基-8-芳基 - [1,2,4]三唑并[1,5-a]吡啶衍生物作为腺苷受体拮抗剂
公开(公告)号：EP1436292A1
公开(公告)日：2004-07-14
申请号：EP02777254.0
申请日：2002-09-28
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P25/16 , A61P25/24
CPC分类号： C07D471/04
摘要： The present application relates to compounds of the formula (I) wherein R1 is hydrogen, halogen or lower alkoxy; R2 is hydrogen or is C(O)- lower alkyl or -C(0)-phenyl, wherein the phenyl ring is unsubstituted or substituted by one or two substituents, selected from the group, consisting of halogen, lower alkoxy or trifluoromethyl, or is -C(O)-furanyl or -C(O)- thiophenyl, wherein the rings are unsubstituted or substituted by halogen; and to their pharmaceutically acceptable salts. The compounds may be used in the treatment of diseases associated with the adenosine A2 receptor.
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公开(公告)号：EP1755593B1
公开(公告)日：2008-01-16
申请号：EP05775021.8
申请日：2005-05-24
发明人： GATTI McARTHUR, Silvia , HERTEL, Cornelia , NETTEKOVEN, Matthias, Heinrich , PLANCHER, Jean-Marc , RAAB, Susanne , ROCHE, Olivier , RODRIGUEZ-SARMIENTO, Rosa Maria , SCHULER, Franz
IPC分类号： A61K31/435 , A61P3/04 , C07D203/18 , C07D217/06 , C07D223/04 , C07D295/08 , C07D295/18
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula (I) wherein A, R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1694673B1
公开(公告)日：2008-01-16
申请号：EP04798115.4
申请日：2004-11-29
IPC分类号： C07D417/06 , C07D277/56 , A61K31/426 , A61K31/427 , A61P25/32 , A61P25/34 , A61P3/04
CPC分类号： C07D417/12 , C07D277/56 , C07D417/06
摘要： The present invention relates to compounds of formula (I)wherein R1, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB 1 receptors.
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