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公开(公告)号：EP1989186B1
公开(公告)日：2010-11-17
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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公开(公告)号：EP1989186A1
公开(公告)日：2008-11-12
申请号：EP07726336.6
申请日：2007-02-12
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
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公开(公告)号：EP1934199B1
公开(公告)日：2009-04-22
申请号：EP06793670.8
申请日：2006-09-20
发明人： BERTHEL, Steven Joseph , ERICKSON, Shawn David , FOTOUHI, Nader , KESTER, Robert Francis , KIM, Kyungjin , MISCHKE, Steven Gregory , QIAN, Yimin , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , WANG, Hong
IPC分类号： C07D401/06
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): wherein A, R1, R2, R4, Ra and Rb are as those disclosed in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
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公开(公告)号：EP1934199A2
公开(公告)日：2008-06-25
申请号：EP06793670.8
申请日：2006-09-20
发明人： BERTHEL, Steven Joseph , ERICKSON, Shawn David , FOTOUHI, Nader , KESTER, Robert Francis , KIM, Kyungjin , MISCHKE, Steven Gregory , QIAN, Yimin , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , WANG, Hong
IPC分类号： C07D401/06
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): wherein A, R1, R2, R4, Ra and Rb are as those disclosed in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
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