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公开(公告)号：EP2488195A2
公开(公告)日：2012-08-22
申请号：EP10770751.5
申请日：2010-10-08
发明人： CONDE-KNAPE, Karin , DANHO, Waleed , FOTOUHI, Nader , FRY, David, C. , KHAN, Wajiha , KONKAR, Anish , RONDINONE, Cristina, Martha , SWISTOK, Joseph , TILLEY, Jefferson, Wright
IPC分类号： A61K38/22
CPC分类号： C07K14/575 , A61K38/00 , C07K14/57545
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
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公开(公告)号：EP1962959A2
公开(公告)日：2008-09-03
申请号：EP06830133.2
申请日：2006-11-27
发明人： CONDE-KNAPE, Karin , DANHO, Waleed , EHRLICH, George , FOTOUHI, Nader , FRY, David C. , KHAN, Wajiha , KONKAR, Anish , RONDINONE, Cristina Martha , SWISTOK, Joseph , TAUB, Rebecca Anne , TILLEY, Jefferson W.
IPC分类号： A61P3/10
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
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3.发明公开
公开(公告)号：EP2904003A1
公开(公告)日：2015-08-12
申请号：EP13774129.4
申请日：2013-10-07
发明人： DEMARTINO, Julie , FOTOUHI, Nader , HOFFMAN, Ann , HUANG, Kuo-Sen , MILLETTI, Francesca , PANICKER, Sandip , SRINIVASAN, Dinesh , TAN, Seng-Lai
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/4702 , C07K2319/10 , G01N21/6408 , G01N21/6428 , G01N33/6872 , G01N2500/04 , G01N2500/20
摘要： The present invention comprises cell penetrating peptides that bind to interferon regulatory factor IRF5 and disrupt the IRF5 homo-dimerization and/or attenuate downstream signaling, and a method for screening peptides that inhibit IRF5. Generally, the cell penetrating peptides of the invention bind human interferon regulatory factor IRF5 (CPP-IRF5).
摘要翻译： 本发明包括结合干扰素调节因子IRF5并破坏IRF5同二聚化和/或减弱下游信号传导的细胞穿透肽，以及用于筛选抑制IRF5的肽的方法。 通常，本发明的细胞穿透肽结合人干扰素调节因子IRF5（CPP-IRF5）。
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4.发明公开
公开(公告)号：EP1979338A1
公开(公告)日：2008-10-15
申请号：EP07703687.9
申请日：2007-01-08
发明人： FOTOUHI, Nader , HALEY, Gregory Jay , SIMONSEN, Klaus B. , VU, Binh Thanh , WEBBER, Stephen Evan
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/04 , C07D413/14 , A61K31/5377 , A61K31/506 , A61K31/496 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/04 , C07D409/14 , C07D413/14
摘要： There are provided compounds of the formula (I), wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
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公开(公告)号：EP1753727A1
公开(公告)日：2007-02-21
申请号：EP05742255.2
申请日：2005-05-10
发明人： FOTOUHI, Nader , HALEY, Gregory, Jay , SIMONSEN, Klaus, B. , VU, Binh, Thanh , WEBBER, Stephen, Evan
IPC分类号： C07D233/22 , C07D233/26 , A61K31/4164 , A61P35/00
CPC分类号： C07D403/06 , C07D233/22 , C07D233/26
摘要： Formula (I) and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3,Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proiferative activity.
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公开(公告)号：EP2870174A1
公开(公告)日：2015-05-13
申请号：EP13734091.5
申请日：2013-07-05
发明人： DANHO, Waleed , FOTOUHI, Nader , HAN, Yi , KHAN, Wajiha , MILLETTI, Francesca , NUI, Huifeng
IPC分类号： C07K14/47
CPC分类号： C07K14/4702 , C07K2319/10
摘要： The present invention provides compounds to disrupt the eIF4E - eIF4G interaction and pharmaceutically acceptable salts of such compounds. Generally, the compounds are cell- penetrating peptides which bind mammalian initiation factor eIF4E (CPP-eIF4E), wherein the peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOS: 7, 9-11, 12-26, 27-44 and 45-51. More preferably, the amino acid sequence comprises at least 9 to about 40 amino acids and the mammalian initiation factor eIF4E is human initiation factor eIF4E.
摘要翻译： 本发明提供了破坏eIF4E-eIF4G相互作用的化合物和这些化合物的药学上可接受的盐。 通常，所述化合物是结合哺乳动物起始因子eIF4E（CPP-eIF4E）的细胞穿透肽，其中所述肽包含选自SEQ ID NOS：7,9-11,12-26,27的氨基酸序列 -44和45-51。 更优选地，氨基酸序列包含至少9至约40个氨基酸，并且哺乳动物起始因子eIF4E是人起始因子eIF4E。
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公开(公告)号：EP1962959B1
公开(公告)日：2012-03-14
申请号：EP06830133.2
申请日：2006-11-27
发明人： CONDE-KNAPE, Karin , DANHO, Waleed , EHRLICH, George , FOTOUHI, Nader , FRY, David C. , KHAN, Wajiha , KONKAR, Anish , RONDINONE, Cristina Martha , SWISTOK, Joseph , TAUB, Rebecca Anne , TILLEY, Jefferson W.
IPC分类号： C07K14/575 , A61K38/10 , A61K38/00
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
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公开(公告)号：EP1753727B1
公开(公告)日：2008-11-19
申请号：EP05742255.2
申请日：2005-05-10
发明人： FOTOUHI, Nader , HALEY, Gregory, Jay , SIMONSEN, Klaus, B. , VU, Binh, Thanh , WEBBER, Stephen, Evan
IPC分类号： C07D233/22 , C07D233/26 , A61K31/4164 , A61P35/00
CPC分类号： C07D403/06 , C07D233/22 , C07D233/26
摘要： Formula (I) and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3,Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proiferative activity.
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9.发明授权
公开(公告)号：EP1924563B1
公开(公告)日：2013-07-31
申请号：EP06792922.4
申请日：2006-08-21
发明人： BANNER, Bruce Lester , BILOTTA, Joseph Anthony , FOTOUHI, Nader , GILLESPIE, Paul , GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , HAYNES, Nancy-Ellen , KOWALCZYK, Agnieszka , MAYWEG, Alexander V. , MYERS, Michael Paul , PIETRANICO-COLE, Sherrie Lynn , SCOTT, Nathan Robert , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , GUERTIN, Kevin Richard
IPC分类号： C07D231/54 , A61P3/00 , A61K31/4184
CPC分类号： C07D231/54
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公开(公告)号：EP1934199B1
公开(公告)日：2009-04-22
申请号：EP06793670.8
申请日：2006-09-20
发明人： BERTHEL, Steven Joseph , ERICKSON, Shawn David , FOTOUHI, Nader , KESTER, Robert Francis , KIM, Kyungjin , MISCHKE, Steven Gregory , QIAN, Yimin , THAKKAR, Kshitij Chhabilbhai , TILLEY, Jefferson Wright , WANG, Hong
IPC分类号： C07D401/06
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): wherein A, R1, R2, R4, Ra and Rb are as those disclosed in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
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