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公开(公告)号：EP1844026B1
公开(公告)日：2011-04-27
申请号：EP06700277.4
申请日：2006-01-10
发明人： BENTLEY, Jonathan, Mark , DAWSON, Claire, Elizabeth , GUBA, Wolfgang , HEBEISEN, Paul , MONCK, Nathaniel , PRATT, Robert, Mark , RICHTER, Hans , ROEVER, Stephan , RUSTON, Vicki
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/04 , A61P3/10
CPC分类号： C07D265/30
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
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公开(公告)号：EP1844026A2
公开(公告)日：2007-10-17
申请号：EP06700277.4
申请日：2006-01-10
发明人： BENTLEY, Jonathan, Mark , DAWSON, Claire, Elizabeth , GUBA, Wolfgang , HEBEISEN, Paul , MONCK, Nathaniel , PRATT, Robert, Mark , RICHTER, Hans , ROEVER, Stephan , RUSTON, Vicki
IPC分类号： C07D265/30 , A61K31/5375 , A61P3/04 , A61P3/10
CPC分类号： C07D265/30
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
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3.发明公开2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 有权-2,5,6,7-四氢 - [1,4]氧氮杂-3-基胺OR -2,3,6,7-四氢 - [1,4]氧氮杂-5-基胺化合物
公开(公告)号：EP2566855A1
公开(公告)日：2013-03-13
申请号：EP11720065.9
申请日：2011-05-03
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , ROMBACH, Didier , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , C07D417/12 , A61K31/553 , A61P25/28
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of the formula (I), wherein A, B and R
1 to R
7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as 5 medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.-
4.发明授权BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES 有权苯并咪唑，氧杂吡啶，苯并噻唑，三唑并吡啶衍生物
公开(公告)号：EP1924579B1
公开(公告)日：2011-02-09
申请号：EP06778310.0
申请日：2006-08-21
发明人： BINGGELI, Alfred , CHRIST, Andreas, D. , GREEN, Luke , GUBA, Wolfgang , MAERKI, Hans, P. , MARTIN, Rainer, E. , MOHR, Peter
IPC分类号： C07D413/12 , C07D413/14 , C07D498/04 , C07D417/12 , C07D417/14 , A61P3/10 , A61P3/04 , A61P17/06 , A61P19/02 , A61K31/428 , A61K31/437 , A61K31/423
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention is concerned with compounds of the formula (I) wherein X, A, B, R1, R2 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to then- use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
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5.发明公开BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES 有权苯并恶唑，恶唑并吡啶，苯并噻唑和噻唑并吡啶衍生物
公开(公告)号：EP1924579A2
公开(公告)日：2008-05-28
申请号：EP06778310.0
申请日：2006-08-21
发明人： BINGGELI, Alfred , CHRIST, Andreas, D. , GREEN, Luke , GUBA, Wolfgang , MAERKI, Hans, P. , MARTIN, Rainer, E. , MOHR, Peter
IPC分类号： C07D413/12 , C07D413/14 , C07D498/04 , C07D417/12 , C07D417/14 , A61P3/10 , A61P3/04 , A61P17/06 , A61P19/02 , A61K31/428 , A61K31/437 , A61K31/423
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention is concerned with compounds of the formula (I) wherein X, A, B, R1, R2 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to then- use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译： 本发明涉及其中X，A，B，R1，R2和G如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 本发明进一步涉及含有这些化合物的药物组合物，其制备方法，然后用于治疗和/或预防与调节SST受体亚型5相关的疾病。
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公开(公告)号：EP3083644A1
公开(公告)日：2016-10-26
申请号：EP14821587.4
申请日：2014-12-17
发明人： GUBA, Wolfgang , HAAP, Wolfgang , KUGLSTATTER, Andreas , PETERS, Jens-Uwe , OBST SANDER, Ulrike , SCHNIDER, Christian , WERMUTH, Roger , WOLTERING, Thomas
IPC分类号： C07D513/04 , A61K31/549 , A61K31/554 , A61P25/28
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：EP2493856B1
公开(公告)日：2016-04-27
申请号：EP10773287.7
申请日：2010-10-25
发明人： GREEN, Luke , GUBA, Wolfgang , JAESCHKE, Georg , JOLIDON, Synese , LINDEMANN, Lothar , RICCI, Antonio , RUEHER, Daniel , STADLER, Heinz , VIEIRA, Eric
IPC分类号： A61K31/4433 , C07D213/64
CPC分类号： C07D213/74 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/505 , A61K31/506 , C07D213/64 , C07D239/34 , C07D239/42 , C07D401/06 , C07D405/12 , C07D413/06 , C07D493/08
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公开(公告)号：EP2558457B1
公开(公告)日：2016-03-09
申请号：EP11713288.6
申请日：2011-04-11
发明人： GREEN, Luke , GUBA, Wolfgang , JAESCHKE, Georg , JOLIDON, Synese , LINDEMANN, Lothar , RICCI, Antonio , RUEHER, Daniel , STADLER, Heinz , VIEIRA, Eric
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D498/04 , A61K31/506 , A61P25/18
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D491/107 , C07D498/04
摘要： The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
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公开(公告)号：EP2513102B1
公开(公告)日：2015-08-19
申请号：EP10790960.8
申请日：2010-12-14
发明人： GREEN, Luke , GUBA, Wolfgang , JAESCHKE, Georg , JOLIDON, Synese , LINDEMANN, Lothar , STADLER, Heinz , VIEIRA, Eric
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4162 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
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10.发明授权2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 有权2,5,6,7-四氢 - [1,4]氧杂环己烯-3-基亚胺ODER 2,3,6,7-四氢 - [1,4]氧杂环己烯-5-木兰VERBINDUNGEN
公开(公告)号：EP2566855B1
公开(公告)日：2014-05-21
申请号：EP11720065.9
申请日：2011-05-03
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , ROMBACH, Didier , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , C07D417/12 , A61K31/553 , A61P25/28
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
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