公开(公告)号：EP3083633A1

公开(公告)日：2016-10-26

申请号：EP14815318.2

申请日：2014-12-16

申请人： F.Hoffmann-La Roche AG

发明人： RUNTZ-SCHMITT, Valerie ,  SCHNIDER, Patrick ,  DOLENTE, Cosimo ,  FASCHING, Bernhard

IPC分类号： C07D491/10 ,  C07D491/12 ,  C07D498/10 ,  A61K31/438 ,  A61P25/00

CPC分类号： C07D491/107 ,  C07D491/10 ,  C07D491/12 ,  C07D491/20 ,  C07D498/10 ,  C07D519/00

摘要： The present invention provides spiro-oxazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, aggressive behavior and phase shift sleep disorders, in particular jetlag.

摘要翻译： 本发明提供作为V1a受体调节剂的螺恶唑酮，特别是作为V1a受体拮抗剂，其制造方法，含有它们的药物组合物及其作为药物的用途。 本发明化合物可用作在血管加压素分泌不适，焦虑症，抑郁障碍，强迫症，自闭症谱系，精神分裂症，侵袭行为和相移睡眠障碍，特别是jetlag中的外周作用和中枢作用的治疗剂。

公开(公告)号：EP1957479A2

公开(公告)日：2008-08-20

申请号：EP06830046.6

申请日：2006-11-20

申请人： F.HOFFMANN-LA ROCHE AG

发明人： NETTEKOVEN, Matthias ,  PLANCHER, Jean-Marc ,  RICHTER, Hans ,  ROCHE, Olivier ,  RUNTZ-SCHMITT, Valerie ,  TAYLOR, Sven

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4439 ,  A61P3/04

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

公开(公告)号：EP1957479B1

公开(公告)日：2011-03-02

申请号：EP06830046.6

申请日：2006-11-20

申请人： F.Hoffmann-La Roche AG

发明人： NETTEKOVEN, Matthias ,  PLANCHER, Jean-Marc ,  RICHTER, Hans ,  ROCHE, Olivier ,  RUNTZ-SCHMITT, Valerie ,  TAYLOR, Sven

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4439 ,  A61P3/04

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

摘要： The present invention relates to compounds of formula (I) wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.