-
公开(公告)号：EP0405421A3
公开(公告)日：1991-06-26
申请号：EP90112076.6
申请日：1990-06-26
发明人： Oohata, Nobutaka , Nishikawa, Motoaki , Kiyoto, Sumio , Takase, Shigehiro , Hemmi, Keiji , Murai, Hidetsugu , Okuhara, Masakuni
IPC分类号： C07C323/61 , C07K5/06 , C07K5/08 , C12P15/00 , A61K31/195 , A61K31/215 , A61K37/02 , C12N1/20
CPC分类号： C12P13/001 , A61K38/00 , C07C323/59 , C07C323/60 , C07C2603/42 , C07K5/0606 , C07K5/081 , Y10S514/929
摘要： A compound of the formula:
wherein
R¹ is hydrogen, hydroxy or acyloxy,
R² is hydrogen or acyl,
R³ is acyl,
R⁴ is hydrogen or acyl,
R⁵ is hydrogen or acyl,
R⁶ is hydrogen or acyl, and
R⁷ is hydrogen or acyl,
and pharmaceutically acceptable salt thereof, processes for the preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptabel, substantially non-toxic carrier or excipient. The invention also comprises biologically pure cultures of the microorganisms Streptomyces sp. No. 89009 (FERM BP-2475) and Pseudomonas cepacia No. 97 (FERM BP-2945).摘要翻译： 下式的化合物，其中R 1是氢，羟基或酰氧基，R 2是氢或酰基，R 3是酰基，R 4是氢或酰基，R 5是氢， 是氢或酰基，R 6是氢或酰基，R 7是氢或酰基，和其药学上可接受的盐，其制备方法和包含它们作为活性成分的药物组合物与药学上可接受的， 基本无毒的载体或赋形剂。 本发明还包括微生物链霉菌（Streptomyces sp。）的生物纯培养物。 No.89009（FERM BP-2475）和洋葱假单胞菌97号（FERM BP-2945）。
-
公开(公告)号：EP0336230A2
公开(公告)日：1989-10-11
申请号：EP89105225.0
申请日：1989-03-23
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： A compound of the formula
wherein the symbols define certain groups or atoms, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also comprises a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 (FERM BP-1667).摘要翻译： 式CHEM的化合物，其中符号定义某些基团或原子，其制备方法和药物组合物，其包含它们作为与药学上可接受的，基本上无毒的载体或赋形剂相结合的活性成分。 本发明还包括微生物链霉菌9326菌株（FERM BP-1667）的生物学纯培养物。
-
3.发明授权Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions 失效生物活性WS 6049物质，其生产方法及其药物组合物
公开(公告)号：EP0095154B1
公开(公告)日：1987-01-14
申请号：EP83104988.7
申请日：1983-05-20
发明人： Kiyoto, Sumio , Nishikawa, Motoaki , Iwami, Morita , Terano, Hiroshi , Kohsaka, Masanobu , Imanaka, Hiroshi
CPC分类号： C12R1/03 , C12P1/06 , Y10S435/825
摘要： Biologically active WS 6049 substances obtainable by culturing a strain belonging to the genus Actinomadura in an aqueous nutrient medium under aerobic conditions and recovering WS 6049-A substance and/or WS 6049-B substance. The invention also relates to a process for preparing the new substances and pharmaceutical compositions comprising such substances as an active ingredient together with a non-toxic, pharmaceutically acceptable carrier.
-
公开(公告)号：EP0327009A1
公开(公告)日：1989-08-09
申请号：EP89101607.3
申请日：1989-01-31
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： This application relates to new compounds called WS-9326A, WS-9326B, and their derivatives having valuable pharmaceutical properties and which are obtainable by culturing a WS-9326A and/or WS-9326B producing strain belonging to the genus Streptomyces in nutrient medium and recovering such compounds or salts thereof from the resultant cultured broth. The invention also relates to a process for the production of such compounds and to pharmaceutical compositions containing them or a pharmaceutically acceptable salt thereof as an active ingredient. The invention furthermore relates to a biologically pure culture of the microorgnism Streptomyces violaceoniger No. 9326 (FERM BP-1667).
Figure 1 Spectrum of Infrared Absorption of WS-9326A in KBr摘要翻译： 本申请涉及称为WS-9326A，WS-9326B及其衍生物的新化合物及其衍生物，其具有有价值的药物性质，可通过在营养培养基中培养属于链霉菌属的WS-9326A和/或WS-9326B生产菌株并回收 来自所得培养肉汤的这些化合物或其盐。 本发明还涉及生产这些化合物的方法和含有它们的药物组合物或其药学上可接受的盐作为活性成分。 本发明还涉及一种生物学纯培养的微型链霉菌（Streptomyces violaceoniger）No.9326（FERM BP-1667）。
-
5.发明公开WS 7739 substances, their preparation and pharmaceutical composition containing the same 失效WS 7739物质，其制备和含有该物质的药物组合物
公开(公告)号：EP0142121A3
公开(公告)日：1986-10-15
申请号：EP84113383
申请日：1984-11-06
IPC分类号： C12P01/06 , C12N01/20 , A61K35/66 , C12R01/465
摘要： @ New biologically active substances - called WS 7739 - having pharmacological activity are prepared by fermentation of a strain belonging to the genus Streptomyces, e.g. Streptomyces phaeofaciens subsp. matsuenensis no. 7739 FERM BP 660 in a nutrient medium containing sources of assimilable carbon and nitrogen under aerobic conditions; pharmaceutical compositions containing these substances as active ingredients are effective in treating deseases, such as asthma, thrombosis etc.
-
公开(公告)号：EP0327009B1
公开(公告)日：1994-07-13
申请号：EP89101607.3
申请日：1989-01-31
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： This application relates to new compounds called WS-9326A, WS-9326B, and their derivatives having valuable pharmaceutical properties and which are obtainable by culturing a WS-9326A and/or WS-9326B producing strain belonging to the genus Streptomyces in nutrient medium and recovering such compounds or salts thereof from the resultant cultured broth. The invention also relates to a process for the production of such compounds and to pharmaceutical compositions containing them or a pharmaceutically acceptable salt thereof as an active ingredient. The invention furthermore relates to a biologically pure culture of the microorgnism Streptomyces violaceoniger No. 9326 (FERM BP-1667).
-
公开(公告)号：EP0336230A3
公开(公告)日：1991-07-17
申请号：EP89105225.0
申请日：1989-03-23
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： A compound of the formula wherein the symbols define certain groups or atoms, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also comprises a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 (FERM BP-1667).
-
8.发明公开Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions 失效生物活性化合物WS 6049，它们的制备和它们的药物组合物的方法。
公开(公告)号：EP0095154A1
公开(公告)日：1983-11-30
申请号：EP83104988.7
申请日：1983-05-20
发明人： Kiyoto, Sumio , Nishikawa, Motoaki , Iwami, Morita , Terano, Hiroshi , Kohsaka, Masanobu , Imanaka, Hiroshi
CPC分类号： C12R1/03 , C12P1/06 , Y10S435/825
摘要： Biologically active WS 6049 substances obtainable by culturing a strain belonging to the genus Actinomadura in an aqueous nutrient medium under aerobic conditions and recovering WS 6049-A substance and/or WS 6049-B substance. The invention also relates to a process for preparing the new substances and pharmaceutical compositions comprising such substances as an active ingredient together with a non-toxic, pharmaceutically acceptable carrier.
摘要翻译： 生物活性WS 6049种物质可获得的通过培养属于马杜拉放线菌属的菌株在有氧条件下于wässrige营养培养基，并回收WS 6049-A物质和/或WS 6049-B物质。 因此，本发明涉及一种制备新的物质和药物组合物与非毒性的，药学上可接受的载体，其包括测试物质作为活性成分的一起。
-
公开(公告)号：EP0336230B1
公开(公告)日：1997-02-12
申请号：EP89105225.0
申请日：1989-03-23
-
10.发明公开
公开(公告)号：EP0405421A2
公开(公告)日：1991-01-02
申请号：EP90112076.6
申请日：1990-06-26
发明人： Oohata, Nobutaka , Nishikawa, Motoaki , Kiyoto, Sumio , Takase, Shigehiro , Hemmi, Keiji , Murai, Hidetsugu , Okuhara, Masakuni
IPC分类号： C07C323/61 , C07K5/06 , C07K5/08 , C12P15/00 , A61K31/195 , A61K31/215 , A61K37/02 , C12N1/20
CPC分类号： C12P13/001 , A61K38/00 , C07C323/59 , C07C323/60 , C07C2603/42 , C07K5/0606 , C07K5/081 , Y10S514/929
摘要： A compound of the formula:
wherein
R¹ is hydrogen, hydroxy or acyloxy,
R² is hydrogen or acyl,
R³ is acyl,
R⁴ is hydrogen or acyl,
R⁵ is hydrogen or acyl,
R⁶ is hydrogen or acyl, and
R⁷ is hydrogen or acyl,
and pharmaceutically acceptable salt thereof, processes for the preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptabel, substantially non-toxic carrier or excipient. The invention also comprises biologically pure cultures of the microorganisms Streptomyces sp. No. 89009 (FERM BP-2475) and Pseudomonas cepacia No. 97 (FERM BP-2945).摘要翻译： 下式的化合物，其中R 1是氢，羟基或酰氧基，R 2是氢或酰基，R 3是酰基，R 4是氢或酰基，R 5是氢， 是氢或酰基，R 6是氢或酰基，R 7是氢或酰基，和其药学上可接受的盐，其制备方法和包含它们作为活性成分的药物组合物与药学上可接受的， 基本无毒的载体或赋形剂。 本发明还包括微生物链霉菌（Streptomyces sp。）的生物纯培养物。 No.89009（FERM BP-2475）和洋葱假单胞菌97号（FERM BP-2945）。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.012 秒)
