公开(公告)号：EP1824805A4

公开(公告)日：2010-01-06

申请号：EP05821819

申请日：2005-12-09

申请人： FUTURECHEM CO LTD ,  ASAN FOUNDATION

发明人： CHI DAE YOON ,  KIM DONG WOOK ,  OH SEUNG JUN ,  RYU JIN-SOOK ,  MOON DAE HYUK

IPC分类号： C07C17/007 ,  C07C69/76 ,  C07C209/02 ,  C07C211/63 ,  C07C215/40 ,  C07C253/30 ,  C07C255/42 ,  C07C303/30 ,  C07C309/73 ,  C07D233/58 ,  C07D233/91 ,  C07D451/02 ,  C07H5/02 ,  C07H19/06 ,  C07J1/00

CPC分类号： C07C209/02 ,  A61K51/1282 ,  B65B3/003 ,  C07B39/00 ,  C07B59/00 ,  C07B59/002 ,  C07B2200/05 ,  C07C213/08 ,  C07C253/30 ,  C07C303/30 ,  C07D213/64 ,  C07D233/91 ,  C07D451/02 ,  C07H5/02 ,  C07H19/06 ,  C07J1/0051 ,  C07C309/73 ,  C07C255/42 ,  C07C211/63 ,  C07C215/40 ,  C07C217/80

摘要： The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having and , respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

公开(公告)号：EP2810926A4

公开(公告)日：2015-09-02

申请号：EP12867630

申请日：2012-12-21

申请人： ASAN FOUNDATION

发明人： LEE SANG JU ,  OH SEUNG JUN ,  MOON DAE HYUK ,  RYU JIN SOOK ,  KIM JAE SEUNG ,  LEE JONG JIN

IPC分类号： C07C21/18 ,  C07B59/00 ,  C07C17/093 ,  G01N33/50

CPC分类号： C07C303/32 ,  A61K51/04 ,  A61K51/0455 ,  C07B59/00 ,  C07B2200/05 ,  C07C213/08 ,  C07C217/80 ,  C07C253/30 ,  C07C309/01 ,  C07D213/64 ,  C07D233/91 ,  C07D403/06 ,  C07D451/02 ,  C07D471/04 ,  C07H19/06 ,  C07C309/04 ,  C07C255/42