专利检索 ap:("Fate Therapeutics, Inc.") AND inv:"TACKE, Robert, Steven" 第 1 页

1.

发明公开
CELLS WITH INCREASED IMMUNO-REGULATORY PROPERTIES AND METHODS FOR THEIR USE AND MANUFACTURE 审中-公开
标题翻译：增强免疫调节特性的细胞及其使用和制造方法

公开(公告)号：EP3250682A1

公开(公告)日：2017-12-06

申请号：EP16743971.0

申请日：2016-01-26

申请人： Fate Therapeutics, Inc.

发明人： ROBBINS, David , REZNER, Betsy , MITCHELL, Leah , GUERRETTAZ, Lisa , PARONE, Philippe, Alessandro , TACKE, Robert, Steven , LAI, Kevin , VALAMEHR, Bahram

IPC分类号： C12N5/0789 , C07J5/00 , C07K14/555 , C12N15/11 , A61K35/12 , A61P37/02

CPC分类号： C12N5/0647 , A61K35/28 , A61K38/1774 , A61K38/44 , A61K2035/124 , A61K2039/577 , A61P29/00 , A61P37/00 , C07K14/555 , C07K14/70532 , C07K14/70596 , C12N5/0636 , C12N9/0069 , C12N2501/02 , C12N2501/056 , C12N2501/24 , C12N2501/48 , C12N2501/51 , C12N2501/599 , C12N2501/71 , C12N2501/999 , C12N2502/1171 , C12Y113/11052

摘要： The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppressive effects obtained by cells expressing increased PD-L1 and/or IDO-1.