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公开(公告)号：EP2785834B1
公开(公告)日：2020-09-23
申请号：EP12854238.8
申请日：2012-11-29
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公开(公告)号：EP3381456A1
公开(公告)日：2018-10-03
申请号：EP18169424.1
申请日：2012-11-29
IPC分类号： A61K31/5575 , A61K31/573 , A61P9/10 , A61P9/00 , A61K35/28 , C12N5/0789 , A61K35/12
CPC分类号： A61K35/28 , A61K31/5575 , A61K31/573 , A61K2035/124 , C12N5/0647 , C12N2501/02 , C12N2501/39 , A61K2300/00
摘要： The invention provides compositions comprising stem and/or progenitor cells that have been treated to enhance the therapeutic properties of the cells for treating ischemia. In particular, the present invention relates to the use of stem and/or progenitor cells having enhanced therapeutic properties to treat an ischemic tissue, a tissue damaged by ischemia, or at least one symptom associated with an ischemic tissue or a tissue damaged by ischemia.
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公开(公告)号：EP2785350B1
公开(公告)日：2018-05-02
申请号：EP12852924.5
申请日：2012-11-29
IPC分类号： A61K31/5575 , A61K31/573 , A61P9/10 , A61P9/00 , A61K35/28 , C12N5/0789 , A61K35/12
CPC分类号： A61K35/28 , A61K31/5575 , A61K31/573 , A61K2035/124 , C12N5/0647 , C12N2501/02 , C12N2501/39 , A61K2300/00
摘要： The invention provides compositions comprising stem and/or progenitor cells that have been treated to enhance the therapeutic properties of the cells for treating ischemia. In particular, the present invention relates to the use of stem and/or progenitor cells having enhanced therapeutic properties to treat an ischemic tissue, a tissue damaged by ischemia, or at least one symptom associated with an ischemic tissue or a tissue damaged by ischemia.
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公开(公告)号：EP2785834A1
公开(公告)日：2014-10-08
申请号：EP12854238.8
申请日：2012-11-29
IPC分类号： C12N5/10 , C12N5/0735 , C12N5/074 , A61K35/12
摘要： The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
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5.发明公开CELLS WITH INCREASED IMMUNO-REGULATORY PROPERTIES AND METHODS FOR THEIR USE AND MANUFACTURE 审中-公开增强免疫调节特性的细胞及其使用和制造方法
公开(公告)号：EP3250682A1
公开(公告)日：2017-12-06
申请号：EP16743971.0
申请日：2016-01-26
发明人： ROBBINS, David , REZNER, Betsy , MITCHELL, Leah , GUERRETTAZ, Lisa , PARONE, Philippe, Alessandro , TACKE, Robert, Steven , LAI, Kevin , VALAMEHR, Bahram
IPC分类号： C12N5/0789 , C07J5/00 , C07K14/555 , C12N15/11 , A61K35/12 , A61P37/02
CPC分类号： C12N5/0647 , A61K35/28 , A61K38/1774 , A61K38/44 , A61K2035/124 , A61K2039/577 , A61P29/00 , A61P37/00 , C07K14/555 , C07K14/70532 , C07K14/70596 , C12N5/0636 , C12N9/0069 , C12N2501/02 , C12N2501/056 , C12N2501/24 , C12N2501/48 , C12N2501/51 , C12N2501/599 , C12N2501/71 , C12N2501/999 , C12N2502/1171 , C12Y113/11052
摘要： The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppressive effects obtained by cells expressing increased PD-L1 and/or IDO-1.
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公开(公告)号：EP2785350A2
公开(公告)日：2014-10-08
申请号：EP12852924.5
申请日：2012-11-29
IPC分类号： A61K31/5575 , A61K31/573 , A61P9/10 , A61P9/00
CPC分类号： A61K35/28 , A61K31/5575 , A61K31/573 , A61K2035/124 , C12N5/0647 , C12N2501/02 , C12N2501/39 , A61K2300/00
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公开(公告)号：EP3278808A1
公开(公告)日：2018-02-07
申请号：EP17188681.5
申请日：2011-08-12
发明人： SHOEMAKER, Daniel , MULTANI, Pratik , DESPONTS, Caroline , ROBBINS, David , GRAYSON, Paul , MENDLEIN, John
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C12N2501/02
摘要： The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
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公开(公告)号：EP3785767A1
公开(公告)日：2021-03-03
申请号：EP20197373.2
申请日：2012-11-29
IPC分类号： A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/16 , A61P27/02
摘要： The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
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公开(公告)号：EP3654986A2
公开(公告)日：2020-05-27
申请号：EP18750040.0
申请日：2018-07-19
发明人： ROSEN, Jonathan , PERALTA, Eigen , HARDY, Ian , REZNER, Betsy D. , MAINE, Christian , SHOEMAKER, Daniel , ROBBINS, David , THOMPSON, Lucas
IPC分类号： A61K31/5517 , A61K31/00 , A61K45/06 , A61K35/17 , A61K41/00 , C07K16/00 , A61K31/573 , A61P37/06 , A61P35/00 , A61P35/02 , A61P31/18 , A61P31/12 , A61K31/4155 , A61K31/517 , A61K31/569
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公开(公告)号：EP3292200A1
公开(公告)日：2018-03-14
申请号：EP16790015.8
申请日：2016-05-04
IPC分类号： C12N5/0783 , C12N5/02 , C07K14/725 , C07K16/00 , A61K35/17 , A61P35/00
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/02 , C12N2501/39 , C12N2510/00 , Y02A50/467
摘要： The present disclosure relates to molecular biology, cell biology and immunology. Specifically, the present disclosure provides compositions and methods for modulating an isolated population of T lymphocytes to improve the therapeutic potential thereof.
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